Endothelial Nitric Oxide Synthase Gene Minisatellite Polymorphism in Populations of the Volga–Ural Region and Analysis of Its Association with Myocardial Infarction and Essential Hypertension

被引：0
作者：
O. E. Mustafina
E.I. Shagisultanova
T.R. Nasybullin
I. A. Tuktarova
A. M. Bikmeeva
O. N. Poluydova
E. K. Khusnutdinova
机构：
[1] Institute of Biochemistry and Genetics,
[2] Ufa Scientific Center,undefined
[3] Russian Academy of Sciences,undefined
[4] Ufa,undefined
来源：
Russian Journal of Genetics | 2001年 / 37卷
关键词：
Polymerase Chain Reaction; Nitric Oxide; Myocardial Infarction; Heart Disease; Cardiovascular Disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The 27-bp tandem repeat polymorphism in intron 4 of the endothelial nitric oxide synthase gene (eNOS) in populations of the Volga–Ural region was studied by means of polymerase chain reaction. In Russians and Tatars, the possible association of this polymorphism with coronary heart disease complicated by either myocardial infarction or by essential hypertension was examined. Russians with essential hypertension associated with hypertrophy of the left ventricle displayed a statistically significant increase of the eNOS4A/Bgenotype and theAallele frequencies along with the decrease of the frequencies of the eNOS4B/Bgenotype and the Ballele. In Tatars survived from myocardial infarction and with the risk of cardiovascular diseases (smoking or burdened heredity), a statistically significant increase of the frequencies of the eNOS4A/Bgenotype and the Aallele was observed. Thus, in Russians the eNOS4A/Bgenotype was associated with the development of essential hypertension, while in Tatars it was associated with the risk of myocardial infarction.
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页码：546 / 552
页数：6
相关论文
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