Latent Autoimmune Diabetes in Adults (LADA)

Greulich B(1993)Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with theHLADQA1*0301-DQB10302 haplotype at clinical type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40 years: The Belgian Diabetes Registry Diabetologia 36 1155-157

Gries FA(1997)Distinct genetic and immunological features in patients with onset of IDDM before and after age 40 Diabetes Care 20 524-457

Henrichs HR(1999)Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies Diabetes 48 150-616

Betrams J(2003)Similar genetic features and different islet cell autoantibody pattern of Latent Autoimmune Diabetes in Adults (LADA) compared with adult-onset type 1 diabetes with rapid progression Diabetes Care 26 452-880

Kolb H.(1999)Genetic heterogeneity of autoimmune diabetes: Age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43) Diabetologia 42 608-659

Hagopian WA(1985)Increased reduction in fasting C-peptide is associated with islet cell antibodies in type 1 (insulin-dependent) diabetic patients Diabetologia 28 875-850

Karlsen AE(1990)Persistence of antibodies to a 64,000-Mr islet cell protein after onset of type I diabetes Diabetes 39 653-80

Gottsater A(1988)Predicting insulin-dependent diabetes Lancet i 845-1753

Landin Olsson M(2000)Insulin and glucagon secretion in patients with slowly progressive autoimmune diabetes (LADA) J Clin Endocrinol Metab 85 76-935

Grubin CE(2001)B-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomized, double blind, phase II trial Lancet 358 1749-1277

Greulich B(1993)Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with theHLADQA1*0301-DQB10302 haplotype at clinical type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40 years: The Belgian Diabetes Registry Diabetologia 36 1155-157

Gries FA(1997)Distinct genetic and immunological features in patients with onset of IDDM before and after age 40 Diabetes Care 20 524-457

Henrichs HR(1999)Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies Diabetes 48 150-616

Betrams J(2003)Similar genetic features and different islet cell autoantibody pattern of Latent Autoimmune Diabetes in Adults (LADA) compared with adult-onset type 1 diabetes with rapid progression Diabetes Care 26 452-880

Kolb H.(1999)Genetic heterogeneity of autoimmune diabetes: Age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43) Diabetologia 42 608-659

Hagopian WA(1985)Increased reduction in fasting C-peptide is associated with islet cell antibodies in type 1 (insulin-dependent) diabetic patients Diabetologia 28 875-850

Karlsen AE(1990)Persistence of antibodies to a 64,000-Mr islet cell protein after onset of type I diabetes Diabetes 39 653-80

Gottsater A(1988)Predicting insulin-dependent diabetes Lancet i 845-1753

Landin Olsson M(2000)Insulin and glucagon secretion in patients with slowly progressive autoimmune diabetes (LADA) J Clin Endocrinol Metab 85 76-935

Grubin CE(2001)B-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomized, double blind, phase II trial Lancet 358 1749-1277