Expression of the c-Fos gene in the rat hypothalamus in electrical pain stimulation and UHF stimulation of the skin

被引:5
|
作者
Novikova N.S. [1 ]
Kazakova T.B. [1 ]
Rogers V. [2 ]
Korneva E.A. [1 ]
机构
[1] Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg 197376
[2] Institute of Bioinformational Studies, Philadelphia
关键词
C-fos expression; Electrical pain stimulation; Hypothalamus; UHF irradiation;
D O I
10.1007/s11055-008-0059-2
中图分类号
学科分类号
摘要
Studies of the pattern of activation of hypothalamic cells in conditions of electrical pain stimulation demonstrated an increase in the proportion of c-Fos-positive cells (to 72.02-98.95%), predominantly affecting cells of size 10-50 μm2. UHF irradiation of the skin activated hypothalamic cells of size 10-70 μm2 in the paraventricular and dorsomedial nuclei and in the periforniceal zone of the lateral hypothalamic field. Combined action of UHF irradiation of the skin and electrical pain stimulation led to decreases in the proportions of cells activated as a result of pain stimulation in the anterior hypothalamic field, the ventromedial nucleus, and the basal part of the lateral hypothalamic field. Changes in the distribution of activated cells by size (mainly a reduction in the proportion of cells of area 10-30 μm2 and an increase in the proportion of larger cells) were detected in the ventromedial nucleus and the basal part of the lateral field. UHF irradiation of the skin was found to have a modifying effect, consisting of a reduction in the degree of activation of hypothalamic cells evoked by electrical pain stimulation. © 2008 Springer Science+Business Media, Inc.
引用
收藏
页码:415 / 420
页数:5
相关论文
共 50 条
  • [1] Intracellular expression of c-Fos protein in various structures of the hypothalamus in electrical pain stimulation and administration of antigens
    Gavrilov Yu.V.
    Perekrest S.V.
    Novikova N.S.
    Neuroscience and Behavioral Physiology, 2008, 38 (1) : 87 - 92
  • [2] EXPRESSION OF C-FOS PROTEIN BY IMMUNOHISTOCHEMICALLY IDENTIFIED OXYTOCIN NEURONS IN THE RAT HYPOTHALAMUS UPON OSMOTIC STIMULATION
    GIOVANNELLI, L
    SHIROMANI, PJ
    JIRIKOWSKI, GF
    BLOOM, FE
    BRAIN RESEARCH, 1992, 588 (01) : 41 - 48
  • [3] Heatstroke induces c-fos expression in the rat hypothalamus
    Tsay, HJ
    Li, HY
    Lin, CH
    Yang, YL
    Yeh, JY
    Lin, MT
    NEUROSCIENCE LETTERS, 1999, 262 (01) : 41 - 44
  • [4] C-FOS PROTEIN EXPRESSION IN THE RAT SUBFORNICAL ORGAN FOLLOWING OSMOTIC STIMULATION
    GIOVANNELLI, L
    BLOOM, FE
    NEUROSCIENCE LETTERS, 1992, 139 (01) : 1 - 6
  • [5] Regional activation in the rat brain during visceral stimulation detected by c-fos expression and fMRI
    Lazovic, J
    Wrzos, HF
    Yang, QX
    Collins, CM
    Smith, MB
    Norgren, R
    Matyas, K
    Ouyang, A
    NEUROGASTROENTEROLOGY AND MOTILITY, 2005, 17 (04): : 548 - 556
  • [6] Fatigue of the Dorsal Neck Muscles Initiates c-fos Expression in the Rat Spinal Cord and Hypothalamus
    Maznychenko, A. V.
    Pilyavskii, A. I.
    Vlasenko, O. V.
    Maisky, V. A.
    NEUROPHYSIOLOGY, 2006, 38 (04) : 298 - 301
  • [7] c-fos expression pattern in the hypothalamus and the preoptic area of the rat during proestrus
    Camacho-Arroyo, I
    Guerra-Araiza, C
    Dominguez, R
    Mendoza-Rodríguez, CA
    Cruz, ME
    Cerbón, MA
    LIFE SCIENCES, 1998, 62 (13) : 1153 - 1159
  • [8] C-FOS EXPRESSION IN THE HYPOTHALAMOPITUITARY SYSTEM INDUCED BY ELECTROACUPUNCTURE OR NOXIOUS-STIMULATION
    PAN, BH
    CASTROLOPES, JM
    COIMBRA, A
    NEUROREPORT, 1994, 5 (13) : 1649 - 1652
  • [9] c-FOS Expression After Hippocampal Deep Brain Stimulation in Normal Rats
    da Silva, Jose C.
    Scorza, Fulvio A.
    Nejm, Mariana B.
    Cavalheiro, Esper A.
    Cukiert, Arthur
    NEUROMODULATION, 2014, 17 (03): : 213 - 217
  • [10] Fatigue of the dorsal neck muscles initiates c-fos expression in the rat spinal cord and hypothalamus
    A. V. Maznychenko
    A. I. Pilyavskii
    O. V. Vlasenko
    V. A. Maisky
    Neurophysiology, 2006, 38 : 298 - 301