Nutritional regulation of gene expression

被引：1

作者：

Brudnak M.A. ^{[1
,2
]}

机构：

[1] MAK Wood, Inc., Thiensville

[2] MAK Wood, Inc., Thiensville, WI 53092

来源：

Theory in Biosciences | 2001年 / 120卷 / 1期

关键词：

CHO; Dipeptidylpeptidase-IV; Drosophila; Feed-back inhibition; Gene expression; Genomeceutical; Glucosamine; Glycobiology; Lectin; Nutrient-sensing; S-Adenosyl-L-Methionine; SAMe; UDP-G1cNAc;

D O I：

10.1007/s12064-001-0033-9

中图分类号：

学科分类号：

摘要：

The human genome has now been mapped with a complete sequence to follow shortly. The race is on to apply the vast amount of information contained in the billions of base-pairs. Concurrently, there is an increased demand from the public for perceived natural products. The nutritional supplement and pharmaceutical industries are broadening their product lines to meet this ever-increasing demand. As the genetic basis of disease becomes more evident, it is clear that the two industries will be forced to turn their attention to nutrients affecting gene expression. Such nutritional regulators of gene expression, or genomeceuticals (Brudnak, 2001), have enormous potential for therapeutic and prophylactic applications in both industries by affecting the integrity and expression of genes. However, there are caveats to this application, which if unheeded, may have disastrous results. This paper explores the idea behind the burgeoning area of genomeceuticals as well as some potential pit-falls that this novel area harbors. Representative examples are presented with a subsequent discussion focusing on the specifics of the application.

引用

页码：64 / 75

页数：11

共 31 条

[1]

Alberts B., Dennis B., Lewis J., Raff M., Roberts K., Watson J.D., ed., (1989)

[2]

Brudnak M.A., Genomic multi-level nutrient-sensing pathways, Med Hyp, (2001)

[3]

Brudnak M., From Genes to Natural Health: A Molecular Rationale for Enzyme Therapy

[4]

Cousins R.J., Nutritional regulation of gene expression, American Journal of Medicine, 106, 1 A, (1996)

[5]

Cousins R.J., Metal elements and gene expression, Annu Rev Nutr, 14, pp. 449-469, (1994)

[6]

Cramer D.W., Et al., Characteristics of women with a family history of ovarian cancer. I. Galactose consumption and metabolism, Cancer, 74, 2, pp. 1309-1317, (1994)

[7]

Daniels M.C., McClain D.A., Crook E.D., Transcriptional regulation of transforming growth factor beta 1 by glucose: Investigation into the role of the hexosamine biosynthesis pathway, Am J Med Sci, 319, pp. 182-142, (2000)

[8]

Ferguson A.T., Evron E., Umbricht C.B., Pandita T.K., Chan T.A., Hermeking H., Marks J.R., Lambers A.R., Futreal P.A., Stampfer M.R., Sukumar S., High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer, Proc Natl Acad Sci USA, 97, 11, pp. 6049-6054, (2000)

[9]

Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., Friedman J.M., Weight-reducing effects of the plasma protein encoded by the Obese gene, Science, 269, pp. 543-546, (1995)

[10]

Kamohara S., Burcelin R., Halaas J.L., Friendman J.M., Charron M.J., Acute stimulation of glucose metabolism in mice by leptin treatment, Nature, 389, pp. 374-377, (1997)

← 1 2 3 4 →