An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

被引：0

作者：

Sabrina M Lehmann

Christina Krüger

Boyoun Park

Katja Derkow

Karen Rosenberger

Jan Baumgart

Thorsten Trimbuch

Gina Eom

Michael Hinz

David Kaul

Piet Habbel

Roland Kälin

Eleonora Franzoni

Agnieszka Rybak

Duong Nguyen

Rüdiger Veh

Olaf Ninnemann

Oliver Peters

Robert Nitsch

Frank L Heppner

Douglas Golenbock

Eckart Schott

Hidde L Ploegh

F Gregory Wulczyn

Seija Lehnardt

机构：

[1] Charité-Universitaetsmedizin Berlin,Department of Neurology

[2] Yonsei University,Department of Biology

[3] Institute of Microscopic Anatomy and Neurobiology,Department of Psychiatry

[4] Johannes Gutenberg-Universitaet Mainz,Division of Infectious Diseases and Immunology, Department of Medicine

[5] Cluster of Excellence NeuroCure,Department of Hepatology and Gastroenterology

[6] Charité-Universitaetsmedizin Berlin,undefined

[7] Institute for Neuropathology,undefined

[8] Charité-Universitaetsmedizin Berlin,undefined

[9] Max Delbrück Center for Molecular Medicine,undefined

[10] Institute of Cell Biology and Neurobiology,undefined

[11] Charité-Universitaetsmedizin Berlin,undefined

[12] Center for Anatomy,undefined

[13] Charité-Universitaetsmedizin Berlin,undefined

[14] Charité-Universitaetsmedizin Berlin,undefined

[15] University of Massachusetts Medical School,undefined

[16] Charité-Universitaetsmedizin Berlin,undefined

[17] Whitehead Institute for Biomedical Research,undefined

来源：

Nature Neuroscience | 2012年 / 15卷

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摘要：

In addition to their function in gene regulation, certain microRNAs can be secreted by cells. Here, the authors show that the microRNA let-7 can cause neurodegeneration by directly activating Toll-like receptor 7 and that individuals with Alzheimer's disease have more let-7b in their cerebrospinal fluid.

引用

页码：827 / 835

页数：8

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