A phase 1 study of anti-TGFβ receptor type-II monoclonal antibody LY3022859 in patients with advanced solid tumors

被引:0
作者
Anthony W. Tolcher
Jordan D. Berlin
Jan Cosaert
John Kauh
Emily Chan
Sarina A. Piha-Paul
Alex Amaya
Shande Tang
Kyla Driscoll
Richard Kimbung
S. R. Prasad Kambhampati
Ivelina Gueorguieva
David S. Hong
机构
[1] South Texas Accelerated Research Therapeutics LLC,
[2] Vanderbilt-Ingram Cancer Center,undefined
[3] Eli Lilly and Company,undefined
[4] UT M.D. Anderson Cancer Center,undefined
[5] Merck KGaA,undefined
来源
Cancer Chemotherapy and Pharmacology | 2017年 / 79卷
关键词
TGFβ; TGFβ receptor; Monoclonal antibody; Solid tumors; Therapy resistance;
D O I
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中图分类号
学科分类号
摘要
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页码:673 / 680
页数:7
相关论文
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[1]  
Massagué J(2008)TGFβ in cancer Cell 134 215-230
[2]  
Wrzesinski SH(2007)Transforming growth factor-β and the immune response: implications for anticancer therapy Clin Cancer Res 13 5262-5270
[3]  
Wan YY(2005)Role of transforming growth factor beta in human cancer J Clin Oncol 23 2078-2093
[4]  
Flavell RA(2011)Switching TGFB from a tumor suppressor to a tumor promoter Curr Opin Genet Dev 21 93-99
[5]  
Elliott RL(2007)Transforming growth factor-beta and the immune response to malignant disease Clin Cancer Res 13 6247-6251
[6]  
Blobe GC(2006)Alterations in components of the TGF-β superfamily signaling pathways in human cancer Cytokine Growth Factor Rev 17 41-58
[7]  
Inman GJ(2010)The polarization of immune cells in the tumour environment by TGFbeta Nat Rev Immunol 10 554-567
[8]  
Teicher BA(2007)Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations Lab Invest 87 1077-1091
[9]  
Levy L(2006)The logic of TGFβ signaling FEBS Lett 580 2811-2820
[10]  
Hill CS(2010)Anti–transforming growth factor β receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells Clin Cancer Res 16 1191-1205