Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome
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作者:
Fabio M. Simoes de Souza
论文数: 0引用数: 0
h-index: 0
机构:Cell and Developmental Biology,Department of Pediatrics
Fabio M. Simoes de Souza
Nicolas Busquet
论文数: 0引用数: 0
h-index: 0
机构:Cell and Developmental Biology,Department of Pediatrics
Nicolas Busquet
Megan Blatner
论文数: 0引用数: 0
h-index: 0
机构:Cell and Developmental Biology,Department of Pediatrics
Megan Blatner
Kenneth N. Maclean
论文数: 0引用数: 0
h-index: 0
机构:Cell and Developmental Biology,Department of Pediatrics
Kenneth N. Maclean
Diego Restrepo
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h-index: 0
机构:Cell and Developmental Biology,Department of Pediatrics
Diego Restrepo
机构:
[1] Cell and Developmental Biology,Department of Pediatrics
[2] School of Medicine,undefined
[3] University of Colorado Anschutz Medical Campus,undefined
[4] University of Colorado Denver,undefined
[5] School of Medicine,undefined
[6] University of Colorado Anschutz Medical Campus,undefined
来源:
Scientific Reports
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摘要:
Down syndrome (DS) is the most common form of congenital intellectual disability. Although DS involves multiple disturbances in various tissues, there is little doubt that in terms of quality of life cognitive impairment is the most serious facet and there is no effective treatment for this aspect of the syndrome. The Ts65Dn mouse model of DS recapitulates multiple aspects of DS including cognitive impairment. Here the Ts65Dn mouse model of DS was evaluated in an associative learning paradigm based on olfactory cues. In contrast to disomic controls, trisomic mice exhibited significant deficits in olfactory learning. Treatment of trisomic mice with the acetylcholinesterase inhibitor galantamine resulted in a significant improvement in olfactory learning. Collectively, our study indicates that olfactory learning can be a sensitive tool for evaluating deficits in associative learning in mouse models of DS and that galantamine has therapeutic potential for improving cognitive abilities.
机构:
Univ Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Ahmed, Md Mahiuddin
Dhanasekaran, A. Ranjitha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Dhanasekaran, A. Ranjitha
Block, Aaron
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Block, Aaron
Tong, Suhong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado Denver, Colorado Sch Publ Hlth, Aurora, CO 80045 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Tong, Suhong
Costa, Alberto C. S.
论文数: 0引用数: 0
h-index: 0
机构:
Rainbow Babies & Childrens Hosp, Case Western Reserve Sch Med, Dept Pediat, Div Pediat Neurol, Cleveland, OH 44106 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Costa, Alberto C. S.
Stasko, Melissa
论文数: 0引用数: 0
h-index: 0
机构:
Rainbow Babies & Childrens Hosp, Case Western Reserve Sch Med, Dept Pediat, Div Pediat Neurol, Cleveland, OH 44106 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Stasko, Melissa
Gardiner, Katheleen J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Univ Colorado Denver, Dept Biochem & Mol Genet, Aurora, CO 80045 USA
Univ Colorado Denver, Human Med Genet & Genom Program, Aurora, CO 80045 USA
Univ Colorado Denver, Neurosci Program, Aurora, CO 80045 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
机构:
New York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USANew York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
Ramakrishna, N.
Meeker, H. C.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Inst Basic Res Dev Disabil, Dept Virol, Staten Isl, NY 10314 USANew York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
Meeker, H. C.
Li, S.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USANew York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
Li, S.
Brown, W. T.
论文数: 0引用数: 0
h-index: 0
机构:New York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
Brown, W. T.
Rao, R.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USANew York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
Rao, R.
El Idrissi, A.
论文数: 0引用数: 0
h-index: 0
机构:
CUNY, Biol & Neurosci Dept, Coll Staten Isl, Staten Isl, NY 10314 USA
New York State Inst Basic Res Dev Disabil, Dept Human Genet, Staten Isl, NY 10314 USANew York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Zhou, Wen-Bo
Miao, Zong-Ning
论文数: 0引用数: 0
h-index: 0
机构:
Wuxi Third Peoples Hosp, Stem Cell Res Lab, Wuxi, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Miao, Zong-Ning
Zhang, Bin
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Zhang, Bin
Long, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Long, Wei
Zheng, Fang-Xiu
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Zheng, Fang-Xiu
Kong, Jing
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Kong, Jing
Yu, Bin
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
机构:
Univ Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Northwestern Univ, Div Hematol Oncol, Chicago, IL 60611 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Kirsammer, Gina
Jilani, Sarah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Ben May Dept Canc res, Chicago, IL 60637 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Jilani, Sarah
Liu, Hui
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Ben May Dept Canc res, Chicago, IL 60637 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Liu, Hui
Davis, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Davis, Elizabeth
Gurbuxani, Sandeep
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Gurbuxani, Sandeep
Le Beau, Michelle M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Le Beau, Michelle M.
Crispino, John D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Northwestern Univ, Div Hematol Oncol, Chicago, IL 60611 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
机构:
Univ Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Ahmed, Md Mahiuddin
Dhanasekaran, A. Ranjitha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Dhanasekaran, A. Ranjitha
Block, Aaron
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Block, Aaron
Tong, Suhong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado Denver, Colorado Sch Publ Hlth, Aurora, CO 80045 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Tong, Suhong
Costa, Alberto C. S.
论文数: 0引用数: 0
h-index: 0
机构:
Rainbow Babies & Childrens Hosp, Case Western Reserve Sch Med, Dept Pediat, Div Pediat Neurol, Cleveland, OH 44106 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Costa, Alberto C. S.
Stasko, Melissa
论文数: 0引用数: 0
h-index: 0
机构:
Rainbow Babies & Childrens Hosp, Case Western Reserve Sch Med, Dept Pediat, Div Pediat Neurol, Cleveland, OH 44106 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Stasko, Melissa
Gardiner, Katheleen J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
Univ Colorado Denver, Dept Biochem & Mol Genet, Aurora, CO 80045 USA
Univ Colorado Denver, Human Med Genet & Genom Program, Aurora, CO 80045 USA
Univ Colorado Denver, Neurosci Program, Aurora, CO 80045 USAUniv Colorado Denver, Dept Pediat, Linda Crn Inst Syndrome, Aurora, CO 80045 USA
机构:
New York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USANew York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
Ramakrishna, N.
Meeker, H. C.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Inst Basic Res Dev Disabil, Dept Virol, Staten Isl, NY 10314 USANew York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
Meeker, H. C.
Li, S.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USANew York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
Li, S.
Brown, W. T.
论文数: 0引用数: 0
h-index: 0
机构:New York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
Brown, W. T.
Rao, R.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USANew York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
Rao, R.
El Idrissi, A.
论文数: 0引用数: 0
h-index: 0
机构:
CUNY, Biol & Neurosci Dept, Coll Staten Isl, Staten Isl, NY 10314 USA
New York State Inst Basic Res Dev Disabil, Dept Human Genet, Staten Isl, NY 10314 USANew York State Inst Basic Res Dev Disabil, Dept Mol Biol, Staten Isl, NY 10314 USA
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Zhou, Wen-Bo
Miao, Zong-Ning
论文数: 0引用数: 0
h-index: 0
机构:
Wuxi Third Peoples Hosp, Stem Cell Res Lab, Wuxi, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Miao, Zong-Ning
Zhang, Bin
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Zhang, Bin
Long, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Long, Wei
Zheng, Fang-Xiu
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Zheng, Fang-Xiu
Kong, Jing
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
Kong, Jing
Yu, Bin
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R ChinaNanjing Med Univ, Changzhou Women & Children Hlth Hosp, Changzhou, Jiangsu, Peoples R China
机构:
Univ Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Northwestern Univ, Div Hematol Oncol, Chicago, IL 60611 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Kirsammer, Gina
Jilani, Sarah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Ben May Dept Canc res, Chicago, IL 60637 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Jilani, Sarah
Liu, Hui
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Ben May Dept Canc res, Chicago, IL 60637 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Liu, Hui
Davis, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Davis, Elizabeth
Gurbuxani, Sandeep
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Gurbuxani, Sandeep
Le Beau, Michelle M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Le Beau, Michelle M.
Crispino, John D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA
Northwestern Univ, Div Hematol Oncol, Chicago, IL 60611 USAUniv Chicago, Ben May Dept Canc res, Chicago, IL 60637 USA