Arjunolic Acid Improves the Serum Level of Vitamin B12 and Folate in the Process of the Attenuation of Arsenic Induced Uterine Oxidative Stress

被引：0
作者：
Moulima Maity
Hasina Perveen
Moumita Dash
Suryashis Jana
Shamima Khatun
Arindam Dey
Amit Kumar Mandal
Sandip Chattopadhyay
机构：
[1] Vidyasagar University,Department of Biomedical Laboratory Science and Management
[2] Vidyasagar University,Clinical Nutrition and Dietetics Division (Funded under UGC Innovative Programme)
[3] Vidyasagar University,Department of Microbiology
[4] Raiganj University,Chemical Biology Laboratory, Department of Sericulture
来源：
Biological Trace Element Research | 2018年 / 182卷 / 1期
关键词：
Arsenic; Uterine oxidative stress; Arjunolic acid; Vitamin B; Folic acid; SAM;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Continuation of prolonged treatment against arsenicosis with conventional chelating therapy is a global challenge. The present study was intended to evaluate the defensive effect of arjunolic acid against arsenic-induced oxidative stress and female reproductive dysfunction. Wistar strain adult female rats were given sodium arsenite (10 mg/kg body weight) in combination with arjunolic acid (10 mg/kg body weight) orally for two estrous cycles. Electrozymographic analysis explored that arjunolic acid co-treatment counteracted As3+-induced ROS production in uterine tissue by stimulating the activities of endogenous enzymatic antioxidants. Arjunolic acid was able to enhance the protection against mutagenic uterine DNA breakage, necrosis, and ovarian–uterine tissue damages in arsenicated rats by improving the ovarian steroidogenesis. The mechanisms might be coupled with the augmentation of antioxidant defense system, partly through the elimination of arsenic with the involvement of S-adenosyl methionine pool where circulating levels of vitamin B12, folic acid, and homocysteine play critical roles as evidenced from our present investigation.
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页码：78 / 90
页数：12
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