Lineage-specific functions of TET1 in the postimplantation mouse embryo

被引：0
作者：
Rita Khoueiry
Abhishek Sohni
Bernard Thienpont
Xinlong Luo
Joris Vande Velde
Michela Bartoccetti
Bram Boeckx
An Zwijsen
Anjana Rao
Diether Lambrechts
Kian Peng Koh
机构：
[1] Stem Cell Institute Leuven,KU Leuven Department of Development and Regeneration
[2] VIB Center for Cancer Biology,KU Leuven Department of Human Genetics
[3] Laboratory for Translational Genetics,undefined
[4] Laboratory for Translational Genetics,undefined
[5] VIB Center for the Biology of Disease,undefined
[6] KU Leuven Department of Human Genetics,undefined
[7] La Jolla Institute for Allergy and Immunology,undefined
来源：
Nature Genetics | 2017年 / 49卷
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摘要：
Kian Peng Koh and colleagues report that TET1 regulates lineage-specific genes in the mouse postimplantation embryo, many of them independently of DNA methylation changes, through regulation of JMJD8 expression. They show that Tet1 deletion causes embryonic defects, which are partially penetrant in an inbred strain but fully lethal in non-inbred mice.
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页码：1061 / 1072
页数：11
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