Idiopathic Fetal Growth Restriction: Repercussion of Modulation in Oxidative Stress

被引：5
作者：
Chandra N. [1 ]
Mehndiratta M. [1 ]
Banerjee B.D. [1 ]
Guleria K. [2 ]
Tripathi A.K. [1 ]
机构：
[1] Department of Biochemistry, University College of Medical Sciences and G T B Hospital, Dilshad Garden, Delhi
[2] Department of Obstetrics & Gynecology, University College of Medical Sciences and G T B Hospital, Dilshad Garden, Delhi
来源：
Indian Journal of Clinical Biochemistry | 2016年 / 31卷 / 1期
关键词：
Idiopathic fetal growth restriction; Malondialdehyde; Oxidative stress; Paraoxonase-1; Total antioxidant capacity;
D O I：
10.1007/s12291-015-0487-z
中图分类号：
学科分类号：
摘要：
Oxidative stress has been proposed as one of the causes involved in idiopathic fetal growth restriction (IFGR). However, the exact relationship between oxidative stress and IFGR is not understood. This study aimed at understanding the role of oxidative stress and antioxidant status in IFGR materno-fetal dyads and matched controls. 75 materno-fetal dyads with IFGR were enrolled with equal number of normal low risk controls. Malondialdehyde (MDA) levels were measured as marker of oxidative stress, while paraoxonase-1 (PON1) activity and total antioxidant capacity (TAC) of serum were measured as markers of antioxidant status. MDA levels were increased in both maternal and cord blood of IFGR neonates as compared to controls (p < 0.001). TAC of serum were found to be decreased in IFGR (both maternal and cord blood) as compared to controls (p < 0.001; p < 0.05, respectively). PON1 activity was found to be decreased in the IFGR mothers while it was found increased in IFGR cord blood (p < 0.01; p < 0.001)). IFGR is a state of increased oxidative stress. Decreased PON1 enzymatic activity in mothers is also associated with IFGR. © 2015, Association of Clinical Biochemists of India.
引用
收藏
页码：30 / 37
页数：7
相关论文
共 29 条
  • [1] Gross T.L., Increased risk to the growth retarded fetus, Intrauterine growth retardation, (1989)
  • [2] Campbell S., Thomas A., Ultrasonic measurement of the fetal head to abdomen circumference ratio in the assessment of growth retardation, Br J Obstet Gynaecol, 84, pp. 165-174, (1977)
  • [3] Quadir M., Bhutta Z.A., Low birth weight in developing countries, Kiess W, pp. 148-162, (2009)
  • [4] Strauss R.S., Adult functional outcome of those born small for gestational age: twenty-six-year follow up of 1970 British birth cohort, J Am Med Assoc, 283, pp. 625-632, (2000)
  • [5] Tumevo T., Lundgren E.M., Neurological and intellectual consequences of being born small-for-gestational-age, Kiess W, pp. 134-147, (2009)
  • [6] Chan P.Y.L., Morris J.M., Leslie G.I., Kelly P.J., Gallery E.D.M., Long term effects of prematurity and intrauterine growth restriction on cardiovascular, renal and metabolic functions, Int J Pediatrics, (2010)
  • [7] Barker D.J., Mothers, babies and disease in later life, (1984)
  • [8] Edwards D.R., Romero R., Kusanovic J.P., Hassan S.S., Mazaki-Tovi S., Vaisbuch E., Et al., Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age, J Matern Fetal Neonatal Med, 24, pp. 362-380, (2011)
  • [9] Wang X., Zuckerman B., Pearson C., Kaufman G., Chen C., Wang G., Et al., Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight, JAMA, 287, pp. 195-202, (2002)
  • [10] Jauniaux E., Poston L., Burton G.J., Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution, Hum Reprod Update, 12, pp. 747-755, (2006)
123