Microfluidic model for in vitro acute Toxoplasma gondii infection and transendothelial migration

被引：0

作者：

Hyunho Kim

Sung-Hee Hong

Hyo Eun Jeong

Sewoon Han

Jinchul Ahn

Jin-A. Kim

Ji-Hun Yang

Hyun Jeong Oh

Seok Chung

Sang-Eun Lee

机构：

[1] Korea University,School of Mechanical Engineering

[2] Massachusetts General Hospital Research Institute,Center for Systems Biology

[3] Korea Diseases Control and Prevention Agency,Division of Vectors and Parasitic Diseases

[4] CellFE,KU

[5] Next & Bio,KIST Graduate School of Converging Science and Technology

[6] Korea University,undefined

来源：

Scientific Reports | / 12卷

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摘要：

The protozoan parasite Toxoplasma gondii (T. gondii) causes one of the most common human zoonotic diseases and infects approximately one-third of the global population. T. gondii infects nearly every cell type and causes severe symptoms in susceptible populations. In previous laboratory animal studies, T. gondii movement and transmission were not analyzed in real time. In a three-dimensional (3D) microfluidic assay, we successfully supported the complex lytic cycle of T. gondii in situ by generating a stable microvasculature. The physiology of the T. gondii-infected microvasculature was monitored in order to investigate the growth, paracellular and transcellular migration, and transmission of T. gondii, as well as the efficacy of T. gondii drugs.

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