Genomic approaches to investigate the pathogenicity of Cryptococcus neoformans

被引：0
作者：
Thomas G. Mitchell
机构：
[1] Duke University Medical Center,Department of Molecular Genetics and Microbiology
来源：
Current Fungal Infection Reports | 2008年 / 2卷 / 3期
关键词：
Quantitative Trait Locus; Mating Type; Cryptococcus Neoformans; Cryptococcosis; Common Quantitative Trait Locus;
D O I：
10.1007/s12281-008-0025-z
中图分类号：
学科分类号：
摘要：
Cryptococcus neoformans, a model pathogenic fungus, exemplifies the application of several genome-wide approaches to investigate fungal pathogenicity. This review focuses on the application of genome-wide approaches to large populations of clinical and environmental isolates rather than to a small number of well-defined laboratory strains. Specific examples include the construction and utilization of genetic linkage maps, analyses of quantitative trait genes and loci, and the use of genome-wide genetic markers in population studies.
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页码：172 / 179
页数：7
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