Implication of EMT induced by TGF-beta1 in pancreatic cancer

被引：12
|
作者：
Yin T. [1 ]
Wang C. [1 ]
Liu T. [1 ]
Zhao G. [1 ]
Zhou F. [1 ]
机构：
[1] Pancreatic Center Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
来源：
Journal of Huazhong University of Science and Technology | 2006年 / 26卷 / 6期
关键词：
pancreatic cancer; TGF-β1; EMT;
D O I：
10.1007/s11596-006-0619-z
中图分类号：
学科分类号：
摘要：
This study examined the implication of EMT induced by TGF-beta1 in pancreatic cancer invasion. TGF-beta1 expression was determined in 29 cases of human pancreatic carcinoma (PC) by immunohistochemistry and the results were compared with those of pathological examination. Moreover, the effects of TGF-beta1 on the phenotype and invasion of pancreatic cancer cell line Panc-1 were also investigated. TGF-beta1 was detected in 12 cases (41.4%) of PC. Significant correlation was found between the expression of TGF-beta1 and lymph node involvement (P=0.047) and the depth of invasion (P=0.035). TGF-beta1 obviously promoted EMT of Panc-1 cell lines and their invasion ability was substantially enhanced. TGF-beta1 may promote the malignancy of pancreatic cancer by triggering EMT.
引用
收藏
页码：700 / 702
页数：2
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