The host type I interferon response to viral and bacterial infections

被引：0
作者：
Andrea K PERRY
Gang CHEN
Dahai ZHENG
Hong TANG
Genhong CHENG
机构：
[1] Immunology and Molecular Genetics,Department of Microbiology
[2] University of California Los Angeles,undefined
[3] Center for Infection and Immunity,undefined
[4] Institute of Biophysics,undefined
[5] Chinese Academy of Sciences,undefined
来源：
Cell Research | 2005年 / 15卷
关键词：
type I interferons; Toll-like receptors; pattern-recognition receptors; virus infections; signaling mechanisms;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Type I interferons (IFN) are well studied cytokines with anti-viral and immune-modulating functions. Type I IFNs are produced following viral infections, but until recently, the mechanisms of viral recognition leading to IFN production were largely unknown. Toll like receptors (TLRs) have emerged as key transducers of type I IFN during viral infections by recognizing various viral components. Furthermore, much progress has been made in defining the signaling pathways downstream of TLRs for type I IFN production. TLR7 and TLR9 have become apparent as universally important in inducing type I IFN during infection with most viruses, particularly by plasmacytoid dendritic cells. New intracellular viral pattern recognition receptors leading to type I IFN production have been identified. Many bacteria can also induce the up-regulation of these cytokines. Interestingly, recent studies have found a detrimental effect on host cells if type I IFN is produced during infection with the intracellular gram-positive bacterial pathogen, Listeria monocytogenes. This review will discuss the recent advances made in defining the signaling pathways leading to type I IFN production.
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页码：407 / 422
页数：15
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