Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs

被引：0

作者：

Qingyong Ji

Antoine Perchellet

Joan M Goverman

机构：

[1] University of Washington,Department of Immunology

[2] Present address: Department of Anatomy and Cell Biology,undefined

[3] University of Kansas Medical Center,undefined

[4] Kansas City,undefined

[5] Kansas,undefined

[6] USA.,undefined

来源：

Nature Immunology | 2010年 / 11卷

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D O I：

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中图分类号：

学科分类号：

摘要：

Whether environmental antigens can elicit autoimmunity remains unclear. Goverman and colleagues show that viral infection breaks self-tolerance via activation of CD8+ T cells expressing dual T cell antigen receptors, without bystander activation or molecular mimicry.

引用

页码：628 / 634

页数：6

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