Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs

被引:0
|
作者
Qingyong Ji
Antoine Perchellet
Joan M Goverman
机构
[1] University of Washington,Department of Immunology
[2] Present address: Department of Anatomy and Cell Biology,undefined
[3] University of Kansas Medical Center,undefined
[4] Kansas City,undefined
[5] Kansas,undefined
[6] USA.,undefined
来源
Nature Immunology | 2010年 / 11卷
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摘要
Whether environmental antigens can elicit autoimmunity remains unclear. Goverman and colleagues show that viral infection breaks self-tolerance via activation of CD8+ T cells expressing dual T cell antigen receptors, without bystander activation or molecular mimicry.
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页码:628 / 634
页数:6
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