RNA interference screen for human genes associated with West Nile virus infection

被引：0
|
作者：
Manoj N. Krishnan
Aylwin Ng
Bindu Sukumaran
Felicia D. Gilfoy
Pradeep D. Uchil
Hameeda Sultana
Abraham L. Brass
Rachel Adametz
Melody Tsui
Feng Qian
Ruth R. Montgomery
Sima Lev
Peter W. Mason
Raymond A. Koski
Stephen J. Elledge
Ramnik J. Xavier
Herve Agaisse
Erol Fikrig
机构：
[1] Section of Infectious Diseases,Department of Internal Medicine,
[2] ,Department of Pathology
[3] Section of Rheumatology,Department of Genetics
[4] Section for Microbial Pathogenesis,Department of Neurobiology
[5] Yale University School of Medicine,undefined
[6] New Haven,undefined
[7] Connecticutt 06520-8031,undefined
[8] USA ,undefined
[9] Center for Computational and Integrative Biology,undefined
[10] and Gastrointestinal Unit,undefined
[11] Massachusetts General Hospital,undefined
[12] Harvard Medical School,undefined
[13] Boston,undefined
[14] Massachusetts 02114,undefined
[15] USA ,undefined
[16] University of Texas Medical Branch,undefined
[17] Galveston,undefined
[18] Texas 77555,undefined
[19] USA,undefined
[20] Department of Systems Biology,undefined
[21] ,undefined
[22] Center for Genetics and Genomics,undefined
[23] Brigham and Women's Hospital,undefined
[24] Harvard Medical School,undefined
[25] Boston,undefined
[26] Massachusetts 02115,undefined
[27] USA,undefined
[28] Weizmann Institute of Science,undefined
[29] L2 Diagnostics,undefined
[30] 300 George Street,undefined
[31] New Haven,undefined
[32] Connecticutt 06511,undefined
[33] USA ,undefined
[34] Howard Hughes Medical Institute,undefined
[35] Chevy Chase,undefined
[36] Maryland 20815-6789,undefined
[37] USA ,undefined
来源：
Nature | 2008年 / 455卷
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摘要：
This manuscript reports a comprehensive systems level description of the molecular signatures governing the interaction of West Nile virus with human cells. A whole-genome human RNA interference gene silencing screen in HeLa cells identified 305 host proteins genes that facilitate West Nile virus infection of human cells. A number of the identified also play a role in the infection of dengue virus, another flavivirus related to West Nile virus. This work highlights differences in the molecular pathogenesis of related flaviviruses, and points to several possible new targets for antiviral drugs
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页码：242 / 245
页数：3
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