MicroRNAs: key regulators of the trophoblast function in pregnancy disorders

被引:0
|
作者
Lingli Liang
Yanjun Chen
Chunyan Wu
Zitong Cao
Linzhen Xia
Jun Meng
Lu He
Chunfen Yang
Zuo Wang
机构
[1] Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province
[2] Hengyang Medical College,Department of Cardiovascular
[3] University of South China,Department of Function
[4] The Third Affiliated Hospital of University of South China,Department of Gynecology
[5] The First Affiliated Hospital of University of South China,undefined
[6] The First Affiliated Hospital of University of South China,undefined
来源
Journal of Assisted Reproduction and Genetics | 2023年 / 40卷
关键词
MicroRNAs; Trophoblast cells; Placenta; Pregnancy disorders;
D O I
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中图分类号
学科分类号
摘要
The placenta is essential for a successful pregnancy and healthy intrauterine development in mammals. During human pregnancy, the growth and development of the placenta are inseparable from the rapid proliferation, invasion, and migration of trophoblast cells. Previous reports have shown that the occurrence of many pregnancy disorders may be closely related to the dysfunction of trophoblasts. However, the function regulation of human trophoblast cells in the placenta is poorly understood. Therefore, studying the factors that regulate the function of trophoblast cells is necessary. MicroRNAs (miRNAs) are small, non-coding, single-stranded RNA molecules. Increasing evidence suggests that miRNAs play a crucial role in regulating trophoblast functions. This review outlines the role of miRNAs in regulating the function of trophoblast cells and several common signaling pathways related to miRNA regulation in pregnancy disorders.
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页码:3 / 17
页数:14
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