Role of matrix Metalloproteinases in pituitary adenoma invasion

被引：1

作者：

Yang C. ^{[1
]}

Bao X. ^{[1
]}

Wang R. ^{[1
]}

机构：

[1] Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing

来源：

Chinese Neurosurgical Journal | / 4卷 / 1期

关键词：

Matrix metalloproteinase; Molecular biology; Pituitary adenoma; Tumor invasion;

D O I：

10.1186/s41016-017-0109-0

中图分类号：

学科分类号：

摘要：

Though pituitary adenomas are benign tumors in most cases, a considerable fraction of PAs behave in a malignant-like manner and invade to the adjacent structures in sellar region, especially the cavernous sinuses. Cancer-cell invasion and metastasis remain a great challenge for physicians and surgeons in spite of emerging advances in drug therapy and surgical Treatment. matrix metalloproteinases, as a family of zinc-dependent endopeptidases, have long been known to be associated with tumor invasion and metastasis mainly via breaking down basement membrane in different tissues. Aberrant expression and activation of matrix metalloproteinases have been detected in invasive pituitary adenomas as in malignancy and correlated to tumor invasion. Therefore, matrix metalloproteinases are considered as promising biomarkers for predicting tumor behavior and even drug targets for novel therapeutic strategies. In this review, we give an overview of the expression, function, regulation and clinical prospects of matrix metalloproteinases, especially focusing on the biological network in which matrix metalloproteinases may be abnormally activated in promoting pituitary adenoma invasion. © 2018 The Author(s).

引用

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