Interleukin-17 and acute coronary syndrome

被引：0
作者：
Sheng-an Su
Hong Ma
Li Shen
Mei-xiang Xiang
Jian-an Wang
机构：
[1] Zhejiang University,Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine
来源：
Journal of Zhejiang University SCIENCE B | 2013年 / 14卷
关键词：
R541.4;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Inflammation plays an important role in atherosclerosis, which is also crucial for acute coronary syndrome (ACS). Recent studies have revealed that interleukin (IL)-17, which was regarded as a pro-inflammatory cytokine, has a dual function in the progress of ACS. In this review, we sum up both experimental and clinical studies on the relevance of IL-17 to atherosclerosis and its complications, and summarize the research progress on the effect of IL-17 on the atherosclerotic plaque stability and ACS onset. Although the studies are controversial and the mechanism remains unclear, we highlight the knowledge of the role of IL-17 in ACS and elucidate its potential mechanism.
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页码：664 / 669
页数：5
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[1]  
Ávalos AM(2012)IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction Biol. Res. 45 193-200
[2]  
Apablaza FA(2010)Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy Circ. Res. 106 1646-1655
[3]  
Quiroz M(2002)Innate and acquired immunity in atherogenesis Nat. Med. 8 1218-1226
[4]  
Toledo V(2007)A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses Cell Res. 17 435-440
[5]  
Peño JP(2010)Emerging role of IL-17 in atherosclerosis J. Innate Immun. 2 325-333
[6]  
Michea L(2010)IL-17A is proatherogenic in high-fat diet-induced and chlamydia pneumoniae infection-accelerated atherosclerosis in mice J. Immunol. 185 5619-5627
[7]  
Irarrázabal CE(2008)The Th17/Treg imbalance in patients with acute coronary syndrome Clin. Immunol. 127 89-97
[8]  
Carrión FA(2013)Pathogenesis of acute coronary syndromes J. Am. Coll. Cardiol. 61 1-11
[9]  
Figueroa FE(1991)Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis Science 251 788-791
[10]  
Baldeviano GC(2012)Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice Arterioscler. Thromb. Vasc. Biol. 32 273-280
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