Basophil activation test as in vitro assay for cisplatin allergy

被引：14

作者：

Viardot-Helmer, A. ^{[1
]}

Ott, H. ^{[1
]}

Sauer, I. ^{[1
]}

Merk, H. F. ^{[1
]}

机构：

[1] Univ Klinikum RWTH Aachen, Hautklin, D-52074 Aachen, Germany

来源：

HAUTARZT | 2008年 / 59卷 / 11期

关键词：

Basophil activation test; Cisplatinum; Anaphylaxis; Drug allergy;

D O I：

10.1007/s00105-008-1653-5

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

During chemoembolization with gemcitabine, mitomycin and cisplatin of a cholangiocellular carcinoma and after receiving iodide contrast media, a 49-year-old patient developed a grade III anaphylactic reaction. We were asked to verify an adverse reaction to contrast media. Using the basophil activation test, we demonstrated a hypersensitivity reaction to cisplatin with distinct induction of CD63-expression on basophilic granulocytes.

引用

页码：883 / 884

页数：3