Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells

被引：0
作者：
Sun-Woong Kang
Wan-Geun La
Jin Muk Kang
Jung-Ho Park
Byung-Soo Kim
机构：
[1] Hanyang University,Department of Chemical Engineering
[2] Hanyang University,Department of Bioengineering
[3] Korea University,Department of Orthopaedic Surgery, Ansan Hospital, College of Medicine
来源：
Biotechnology Letters | 2008年 / 30卷
关键词：
Bone marrow-derived stem cell; Bone morphogenetic protein-2; Bone regeneration; Tissue engineering;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs.
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页码：1163 / 1168
页数：5
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