Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

被引：0
作者：
Rachael Thomas
Huixia J. Wang
Pei-Chien Tsai
Cordelia F. Langford
Susan P. Fosmire
Cristan M. Jubala
David M. Getzy
Gary R. Cutter
Jaime F. Modiano
Matthew Breen
机构：
[1] North Carolina State University,Department of Molecular Biomedical Sciences, College of Veterinary Medicine
[2] North Carolina State University,Center for Comparative Medicine and Translational Research
[3] North Carolina State University,Department of Statistics, College of Agriculture and Life Sciences
[4] Microarray Facility,Integrated Department of Immunology
[5] The Wellcome Trust Sanger Institute,Department of Biostatistics
[6] University of Colorado,Department of Veterinary Clinical Sciences, College of Veterinary Medicine
[7] Idexx Veterinary Services,Masonic Cancer Center
[8] University of Alabama Birmingham,undefined
[9] University of Colorado Cancer Center,undefined
[10] University of Minnesota,undefined
[11] University of Minnesota,undefined
来源：
Chromosome Research | 2009年 / 17卷
关键词：
microarray; comparative genomic hybridization (CGH); canine; osteosarcoma; chromosome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recurrent chromosomal aberrations in solid tumors can reveal the genetic pathways involved in the evolution of a malignancy and in some cases predict biological behavior. However, the role of individual genetic backgrounds in shaping karyotypes of sporadic tumors is unknown. The genetic structure of purebred dog breeds, coupled with their susceptibility to spontaneous cancers, provides a robust model with which to address this question. We tested the hypothesis that there is an association between breed and the distribution of genomic copy number imbalances in naturally occurring canine tumors through assessment of a cohort of Golden Retrievers and Rottweilers diagnosed with spontaneous appendicular osteosarcoma. Our findings reveal significant correlations between breed and tumor karyotypes that are independent of gender, age at diagnosis, and histological classification. These data indicate for the first time that individual genetic backgrounds, as defined by breed in dogs, influence tumor karyotypes in a cancer with extensive genomic instability.
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页码：365 / 377
页数：12
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