Iodine-catalyzed synthesis of pyrazolo[4,3-f]quinoline derivatives via a highly regio-selective Povarov reaction

被引：0
|
作者：
Mei-Mei Zhang
Wei Wang
Tuan-Jie Li
Chang-Sheng Yao
Xiang-Shan Wang
机构：
[1] Jiangsu Normal University,The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province
[2] Jiangsu Normal University,School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials
来源：
Research on Chemical Intermediates | 2013年 / 39卷
关键词：
Pyrazolo[4,3-; ]quinoline; 1; -indazol-5-amine; Regio-selectivity; Iodine; Synthesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A highly regio-selective Povarov reaction of an aromatic aldehyde, 1H-indazol-5-amine, and methyl 3-oxobutanoate catalyzed by iodine is described. This novel reaction selectively gave 3H-pyrazolo[4,3-f]quinolin-9-yl acetates, in high yield, rather than 3H-pyrazolo[4,3-f]quinoline-8-carboxylate derivatives. This procedure has the advantages of mild reaction conditions, high yields, metal-free catalyst, and high regio-selectivity.
引用
收藏
页码：1781 / 1787
页数：6
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