Extracellular volume fraction assessed using cardiovascular magnetic resonance can predict improvement in left ventricular ejection fraction in patients with dilated cardiomyopathy

被引:0
作者
Keisuke Inui
Kuniya Asai
Masaki Tachi
Aya Yoshinaga
Yuki Izumi
Yoshiaki Kubota
Koji Murai
Yayoi Tetsuou Tsukada
Yasuo Amano
Shinichiro Kumita
Wataru Shimizu
机构
[1] Nippon Medical School,Department of Cardiovascular Medicine
[2] Nippon Medical School,Department of Radiology
[3] Nihon University Hospital,Department of Radiology
来源
Heart and Vessels | 2018年 / 33卷
关键词
T1 mapping; Dilated cardiomyopathy; Heart failure; Remodeling;
D O I
暂无
中图分类号
学科分类号
摘要
T1 mapping using cardiac magnetic resonance (CMR) is useful for myocardial assessment. However, its prognostic value is not well defined. The aim of this study was to determine whether T1 mapping with CMR can predict reverse cardiac remodeling in patients with non-ischemic dilated cardiomyopathy (NIDCM). We also investigated the predictive prognostic value of T1 mapping with CMR in these patients. We included 33 patients with NIDCM admitted to Nippon Medical School Hospital between February 2012 and October 2015. All patients underwent CMR and echocardiography for clinical assessment within 1 month of admission (13 ± 16 days). Follow-up echocardiography was performed no sooner than 6 months after the initial echocardiogram (536 ± 304 days). We evaluated the correlations between native and post-contrast T1 values/extracellular volume fraction (ECV) and the difference in left ventricular ejection fraction (ΔLVEF) determined at baseline and follow-up echocardiography. No correlation was noted between ΔLVEF and native (p = 0.150, r = − 0.256) or post-contrast T1 values (p = 0.956, r = − 0.010). However, a significant and substantial correlation was found between ΔLVEF and ECV (p = 0.043, r = − 0.355). Four patients were hospitalized for heart failure (HF), but no cardiovascular-related deaths occurred over a median follow-up period of 34 months (interquartile range 25–49 months). Kaplan–Meier curves stratified by the median value of ECV were created. The higher ECV groups experienced a significantly higher incidence of HF-related hospitalization (p = 0.0159). ECV measured by CMR can predict improvements in LVEF in patients with NIDCM. In addition, ECV may be a predictive factor for HF-related hospitalization.
引用
收藏
页码:1195 / 1203
页数:8
相关论文
共 464 条
[1]  
Arbustini E(2014)The MOGE(S) classification of cardiomyopathy for clinicians J Am Coll Cardiol 64 304-318
[2]  
Narula N(2008)Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases Eur Heart J 29 270-276
[3]  
Tavazzi L(2000)Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy N Engl J Med 342 1077-1084
[4]  
Serio A(2003)Interstitial fibrosis in the dilated non-ischaemic myocardium Heart 89 1255-1256
[5]  
Grasso M(2011)Assessment of myocardial fibrosis with cardiovascular magnetic resonance J Am Coll Cardiol 57 891-903
[6]  
Favalli V(2012)Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology Eur Heart J 33 1268-1278
[7]  
Bellazzi R(2016)Superiority of the extracellular volume fraction over the myocardial T1 value for the assessment of myocardial fibrosis in patients with non-ischemic cardiomyopathy Magn Reson Imaging 34 1141-1145
[8]  
Tajik JA(2012)Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience J Cardiovasc Magn Reson 14 64-484
[9]  
Bonow RO(2013)Native T1 mapping in differentiation of normal myocardium from diffuse disease in hypertrophic and dilated cardiomyopathy JACC Cardiovasc Imaging 6 475-216
[10]  
Fuster V(2015)T1 mapping in dilated cardiomyopathy with cardiac magnetic resonance: quantification of diffuse myocardial fibrosis and comparison with endomyocardial biopsy Eur Heart J Cardiovasc Imaging 16 210-22