Management of dyslipidemia after allogeneic hematopoietic stem cell transplantation

被引：0
作者：
Yingxue Lu
Xiaojing Ma
Jie Pan
Rongqiang Ma
Yujie Jiang
机构：
[1] Shandong Provincial Hospital Affiliated to Shandong First Medical University,Department of Cardiology
[2] Shandong Provincial Hospital Affiliated to Shandong First Medical University,Department of Hematology
[3] Shandong Provincial Hospital Affiliated to Shandong First Medical University,undefined
来源：
Lipids in Health and Disease | / 21卷
关键词：
Allogeneic hematopoietic stem cell transplantation; Dyslipidemia; Graft-versus-host disease; Statins; Proprotein convertase subtilisin/Kexin type 9 (PCSK9);
D O I：
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摘要：
Dyslipidemia is one of the complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and it is often underestimated and undertreated. Dyslipidemia in allo-HSCT recipients has been confirmed to be associated with endocrine dysfunction, acute and chronic graft-versus-host disease (aGVHD and cGVHD), immunosuppressive agent application, etc. However, few studies have illustrated the accurate molecular signaling pathways involved in dyslipidemia, and there are no standard guidelines for dyslipidemia management after HSCT. This review will discuss the pathogenesis of dyslipidemia, especially the association with aGVHD and/or cGVHD. Comprehensive treatment methods for dyslipidemia after HSCT will also be summarized.
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