Use of the frontal assessment battery in evaluating executive dysfunction in patients with Huntington’s disease

被引:0
|
作者
Guilherme Riccioppo Rodrigues
Carolina Pinto Souza
Roberto Satler Cetlin
Daniel Sabino de Oliveira
Marcio Pena-Pereira
Liliana Tiemi Ujikawa
Wilson Marques
Vitor Tumas
机构
[1] University of São Paulo,Department of Neurosciences and Behavior Sciences, Ribeirão Preto School of Medicine
来源
Journal of Neurology | 2009年 / 256卷
关键词
Huntington’s disease; Executive function; Frontal assessment battery;
D O I
暂无
中图分类号
学科分类号
摘要
The frontal assessment battery (FAB) is a bedside cognitive scale designed to measure executive functions. Huntington’s disease (HD) is a neurodegenerative disorder characterized by motor, behavioral, and cognitive dysfunction. The aim of this study was to check the validity of the FAB for the evaluation of cognitive impairment in patients with HD. Forty-one patients diagnosed with HD and 53 healthy controls matched by education, sex and age were evaluated with a validated Brazilian version of the UHDRS, the VFT, the SDMT, the SIT, the MMSE, and the FAB. The diagnosis of HD was made by DNA analysis. FAB scores were lower in patients than in the controls (p < 0.001) and had significant correlations with the VFT (r = 0.79; p < 0.05), the SDMT (r = 0.80; p < 0.05), the SIT (r = 0.72; p < 0.05), the MMSE (r = 0.83; p < 0.05), the FCS (r = 0.79; p < 0.05) and the motor section of the UHDRS (r = −0.80; p < 0.05). The FAB differentiated between HD patients in the initial and later stages of the disease. The one-year longitudinal evaluation revealed a global trend toward a worsening in the second score of the FAB. The results demonstrate that the FAB presents good internal consistency and also convergent and discriminative validity; therefore it is a useful scale to assess executive functions and to evaluate cognitive impairment in patients with HD.
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页码:1809 / 1815
页数:6
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