TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling

被引：0

作者：

Pauline Martin

Vilas Wagh

Surya A. Reis

Serkan Erdin

Roberta L. Beauchamp

Ghalib Shaikh

Michael Talkowski

Elizabeth Thiele

Steven D. Sheridan

Stephen J. Haggarty

Vijaya Ramesh

机构：

[1] Massachusetts General Hospital,Center for Genomic Medicine

[2] MERCK Research Laboratories,Department of Neurology

[3] Massachusetts General Hospital,Center for Quantitative Health

[4] Massachusetts General Hospital,undefined

来源：

Molecular Autism | / 11卷

关键词：

Tuberous sclerosis complex; TSC1; mTORC1; Induced pluripotent stem cells; Neural progenitor cells; Early neurodevelopment; Disease modeling; CRISPR/Cas9; MEK-ERK1/2; MNK1/2-eIF4E;

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