Do interleukin-6 and macrophage-migration inhibitory factor play a role during sex-associated susceptibility in murine cysticercosis?

被引：0

作者：

Jorge Morales-Montor

Salman Baig

Ahmed Kabbani

Raymond T. Damian

机构：

[1] Departamento de Inmunología,

[2] Instituto de Investigaciones Biomédicas,undefined

[3] UNAM,undefined

[4] AP 70228,undefined

[5] Mexico DF 04510,undefined

[6] Mexico,undefined

[7] Department of Cellular Biology and Center for Tropical and Emerging Global Diseases,undefined

[8] University of Georgia,undefined

[9] Athens,undefined

[10] GA 30602,undefined

[11] USA,undefined

来源：

Parasitology Research | 2002年 / 88卷

关键词：

Serum Level; Testosterone; Estradiol; Male Mouse; Chronic Infection;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In murine Taenia crassiceps cysticercosis, females sustain larger intensities of infection than males. However, during chronic infection, this difference disappears and males show a feminization process. To further study the role of two cytokines, interleukin-6 (IL-6) and macrophage-migration inhibitory factor (MIF), known to be involved in immunoendocrinological processes during sex-associated susceptibility in cysticercosis, IL-6 and MIF gene knockout (KO) mice were infected, and the number of parasites and serum sex-steroid levels were measured. Results show that IL-6 and MIF KO mice of both genders infected with T. crassiceps cysticerci harbor similar numbers of parasites, with no change in sex-hormone levels. However, in wild-type strains, females have twice as many parasites as males. At the same time, there is a decrease of 80% in testosterone and dihydrotestosterone serum levels, and a 100-fold increase in the levels of estradiol in infected male mice. These results suggest a role for both IL-6 and MIF genes in sex-associated susceptibility in murine T. crassiceps cysticercosis.

引用

页码：901 / 904

页数：3