Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report

被引：0

作者：

Toni T. Seppälä

Aysel Ahadova

Mev Dominguez-Valentin

Finlay Macrae

D. Gareth Evans

Christina Therkildsen

Julian Sampson

Rodney Scott

John Burn

Gabriela Möslein

Inge Bernstein

Elke Holinski-Feder

Kirsi Pylvänäinen

Laura Renkonen-Sinisalo

Anna Lepistö

Charlotte Kvist Lautrup

Annika Lindblom

John-Paul Plazzer

Ingrid Winship

Douglas Tjandra

Lior H. Katz

Stefan Aretz

Robert Hüneburg

Stefanie Holzapfel

Karl Heinimann

Adriana Della Valle

Florencia Neffa

Nathan Gluck

Wouter H. de Vos tot Nederveen Cappel

Hans Vasen

Monika Morak

Verena Steinke-Lange

Christoph Engel

Nils Rahner

Wolff Schmiegel

Deepak Vangala

Huw Thomas

Kate Green

Fiona Lalloo

Emma J. Crosbie

James Hill

Gabriel Capella

Marta Pineda

Matilde Navarro

Ignacio Blanco

Sanne ten Broeke

Maartje Nielsen

Ken Ljungmann

Sigve Nakken

Noralane Lindor

机构：

[1] Helsinki University Central Hospital,Department of Surgery

[2] University of Helsinki,Department of Tumor Biology, Institute of Cancer Research

[3] Heidelberg University Hospital and DKFZ,Department of Medical Genetics, The Norwegian Radium Hospital

[4] The Norwegian Radium Hospital,Medical Genetics

[5] part of Oslo University Hospital,Dept. of Surgical Gastroenterology

[6] Oslo University Hospital,Department of Clinical Genetics

[7] The Royal Melbourne Hospital,Institute of Human Genetics

[8] University of Melbourne,Department of Internal Medicine I

[9] University of Manchester & Manchester University Hospitals Foundation Trust,Center for Hereditary Tumor Syndromes

[10] The Danish HNPCC Register,Institute for Medical Genetics and Pathology

[11] Clinical Research Centre,Department of Gastroenterology and Hepatology

[12] Copenhagen University Hospital,Department of Gastroenterology and Hepatology

[13] Cardiff University,Institute for Medical Informatics, Statistics and Epidemiology

[14] University of Newcastle and the Hunter Medical Research Institute,Medical School, Institute of Human Genetics

[15] University of Newcastle,Department of Medicine, Knappschaftskrankenhaus

[16] University Witten-Herdecke,St Mark’s Hospital, Department of Surgery and Cancer

[17] Aalborg University Hospital,Department of Surgical Gastroenterology

[18] Medizinische Klinik und Poliklinik IV,Department of Health Sciences Research

[19] Campus Innenstadt,Center for Bioinformatics, Department of Informatics

[20] Klinikum der Universität München,Department of Medical Genetics

[21] MGZ- Medical Genetics Center,Department of Surgery

[22] Central Finland Central Hospital,Faculty of Sport and Health Sciences

[23] Education and Research,undefined

[24] Aalborg University Hospital,undefined

[25] Karolinska Institutet,undefined

[26] Hadassah Medical Center,undefined

[27] Jerusalem,undefined

[28] and Sheba Medical Center,undefined

[29] University of Bonn,undefined

[30] University Hospital Bonn,undefined

[31] University Hospital Bonn,undefined

[32] University Hospital Basel,undefined

[33] Hospital Fuerzas Armadas,undefined

[34] Grupo Colaborativo Uruguayo,undefined

[35] Investigación de Afecciones Oncológicas Hereditarias (GCU),undefined

[36] Tel-Aviv Soursky Medical Center,undefined

[37] Isala Clinics,undefined

[38] Leiden University Medical Centre,undefined

[39] University of Leipzig,undefined

[40] Heinrich-Heine-University,undefined

[41] Ruhr-University Bochum,undefined

[42] Imperial College London,undefined

[43] University of Manchester and St Mary’s Hospital,undefined

[44] Hereditary Cancer Program,undefined

[45] Catalan Institute of Oncology,undefined

[46] Insititut d’Investigació Biomèdica de Bellvitge (IDIBELL),undefined

[47] ONCOBELL Program,undefined

[48] L’Hospitalet de Llobregat,undefined

[49] Centro de Investigación Biomédica en Red de Cáncer (CIBERONC),undefined

[50] University Medical Center Groningen,undefined

来源：

Hereditary Cancer in Clinical Practice | / 17卷

关键词：

Mismatch repair; Microsatellite instability; Lynch syndrome; Hereditary cancer; Colorectal cancer; Hereditary nonpolyposis colorectal cancer; Colonoscopy; Endoscopy; Surveillance; Screening; Over-diagnosis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 28 条

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Rabban, Joseph T.
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[24] No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study
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JOURNAL OF CLINICAL MEDICINE, 2021, 10 (13)
[25] Identification and classification of hereditary nonpolyposis colorectal cancer (Lynch syndrome): Adapting old concepts to recent advancements. Report from the Italian association for the study of hereditary colorectal tumors consensus group
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[26] Using a multistep approach with multidisciplinary team to increase the diagnosis rate of Lynch syndrome-associated colorectal cancer after universal screening: a single-center study in Japan
Kyota Tatsuta
Mayu Sakata
Moriya Iwaizumi
Risa Kojima
Katsumasa Yamanaka
Satoshi Baba
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Hirotoshi Kikuchi
Yoshihiro Hiramatsu
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Hereditary Cancer in Clinical Practice, 21
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FRONTIERS IN GENETICS, 2022, 12

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