Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer

被引：0
作者：
Manon Buijs
Josephina A. Vossen
Jean-Francois H. Geschwind
Takayoshi Ishimori
James M. Engles
Obele Acha-Ngwodo
Richard L. Wahl
Mustafa Vali
机构：
[1] Division of Vascular and Interventional Radiology,Russell H. Morgan Department of Radiology, and Radiological Sciences
来源：
Investigational New Drugs | 2009年 / 27卷
关键词：
Breast cancer; 3-Bromopyruvate; FDG; RMT; Animal model;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose: To evaluate the anti-glycolytic effects of 3-BrPA on rats bearing RMT mammary tumors, by determining FDG uptake after intravenous administration of the therapeutic dose. Materials and Methods: Sixteen rats bearing RMT tumors were treated either with 15 mM 3-BrPA in 2.5 ml of PBS or with 2.5 ml of PBS. After treatment, all rats received FDG and were sacrificed 1 h later. Results: 3-BrPA treatment significantly decreased FDG uptake in tumors by 77% (p = 0.002). FDG uptake did not significantly decrease in normal tissues after treatment. Conclusion: Our study showed that 3-BrPA exhibits a strong anti-glycolytic effect on RMT cells implanted in rats.
引用
收藏
相关论文
共 85 条
[1]  
Jemal A(2008)Cancer statistics, 2008 CA Cancer J Clin 58 71-96
[2]  
Siegel R(2005)Understanding breast cancer risk—where do we stand in 2005? J Cell Mol Med 9 208-221
[3]  
Ward E(2007)Uncommon breast tumors in perspective: incidence, treatment and survival in The Netherlands Int J Cancer 121 127-135
[4]  
Dumitrescu RG(2006)Surgery for liver metastases from breast cancer HPB Oxf 8 97-99
[5]  
Cotarla I(1999)Current management of metastatic breast cancer Semin Oncol 26 1-10
[6]  
Louwman MW(2007)Impact of chemotherapy in women with metastatic breast cancer diagnosed 1990–2003 Clin Breast Cancer 7 801-803
[7]  
Vriezen M(2007)Evaluating distant metastases in breast cancer: from biology to outcomes Cancer Metastasis Rev 26 663-674
[8]  
van Beek MW(2003)CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment Semin Radiat Oncol 13 176-181
[9]  
Elias D(2004)Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma Expert Rev Anticancer Ther 4 449-457
[10]  
Pietroantonio DD(2005)Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis Carcinogenesis 26 2095-2104
123456789