The Interleukin-6 inflammation pathway from cholesterol to aging - Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases

被引：56
作者：
Omoigui S. [1 ]
机构：
[1] Division of Inflammation and Pain Medicine, L.A Pain Clinic, Los Angeles, CA 90250
来源：
Immunity & Ageing | / 4卷 / 1期
关键词：
Atorvastatin; Flow Mediate Dilatation; Mevalonate Pathway; Farnesyl Pyrophosphate; Mediate Inflammation;
D O I：
10.1186/1742-4933-4-1
中图分类号：
学科分类号：
摘要：
We describe the inflammation pathway from Cholesterol to Aging. Interleukin 6 mediated inflammation is implicated in age-related disorders including Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, Osteoporosis, Type 2 Diabetes, Dementia and Alzheimer's disease and some forms of Arthritis and Cancer. Statins and Bisphosphonates inhibit Interleukin 6 mediated inflammation indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion. Polyphenolic compounds found in plants, fruits and vegetables inhibit Interleukin 6 mediated inflammation by direct inhibition of the signal transduction pathway. Therapeutic targets for the control of all the above diseases should include inhibition of Interleukin-6 mediated inflammation. © 2007 Omoigui; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 159 条
[1]  
Huang H., Patel D.D., Manton K.G., The immune system in aging: Roles of cytokines, T cells and NK cells, Front Biosci, 10, pp. 192-215, (2005)
[2]  
Hackam D.G., Anand S.S., Emerging risk factors for atherosclerotic vascular disease: A critical review of the evidence, JAMA, 290, pp. 932-940, (2003)
[3]  
Ross R., Atherosclerosis an inflammatory disease, N Engl J Med, 340, pp. 115-126, (1999)
[4]  
Libby P., Ridker P.M., Maser A., Inflammation and atherosclerosis, Circulation, 105, pp. 1135-1143, (2002)
[5]  
Ross R., Cell biology of atherosclerosis, Annu Rev Physiol, 57, pp. 791-804, (1995)
[6]  
Tabas I., Free cholesterol-induced cytotoxicity. A possible contributing factor to macrophage foam cell necrosis in advanced atherosclerotic lesions, Trends Cardiovasc Med, 7, pp. 256-263, (1997)
[7]  
Kockx M.M., Apoptosis in the atherosclerotic plaque: Quantitative and qualitative aspects, Arterioscler Thromb Vasc Biol, 18, pp. 1519-1522, (1998)
[8]  
Mitchinson M.J., Hardwick S.J., Bennett M.R., Cell death in atherosclerotic plaques, Curr Opin Lipidol, 7, pp. 324-329, (1996)
[9]  
Bonetti P.O., Lerman L.O., Napoli C., Lerman A., Statin effects beyond lipid lowering - Are they clinically relevant?, Eur Heart J, 24, 3, pp. 225-248, (2003)
[10]  
Davignon J., Mabile L., Mechanisms of action of statins and their pleiotropic effects, Ann Endocrinol (Paris), 62, 1 PART 2, pp. 101-112, (2001)
12345678910