Structural themes in ion channels

被引：0
作者：
Declan A. Doyle
机构：
[1] University of Oxford,Structural Genomics Consortium
[2] Botnar Research Centre,undefined
来源：
European Biophysics Journal | 2004年 / 33卷
关键词：
Electrostatic sinks; Ion binding sites; Ion conduction pathways; Helix dipoles; Hydrophobic gates;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The recent crystal structure of the prokaryotic inwardly rectifying potassium channel, KirBac1.1, revealed for the first time the structure of a K+ channel in the closed state plus the location of the activation gate. Comparison of the KirBac1.1 structure with other known ion channels reveals a number of common structural features. These common characteristics include the formation of the ion conduction pathway at the interface between adjacent subunits, non-fixed charges forming part of the ion pathway, electrostatic sinks drawing ions into the channel, helix dipoles, and hydrophobic gates that ultimately prevent ion movement. This review describes in detail common structural themes present in ion channels.
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页码：175 / 179
页数：4
相关论文
共 27 条
[1]  
Arseniev Y(1985)Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel FEBS Lett 186 168-660
[2]  
Beckstein Y(2001)undefined J Phys Chem B 105 12902-undefined
[3]  
Brelidze undefined(2003)undefined Proc Natl Acad Sci USA 100 9017-undefined
[4]  
Chang undefined(1998)undefined Science 282 2220-undefined
[5]  
Chen undefined(2001)undefined Proc Natl Acad Sci USA 98 11277-undefined
[6]  
Cortes undefined(2001)undefined J Gen Physiol 117 165-undefined
[7]  
Doyle undefined(1998)undefined Science 280 69-undefined
[8]  
Fakler undefined(1994)undefined FEBS Lett 356 199-undefined
[9]  
Ficker undefined(1994)undefined Science 266 1068-undefined
[10]  
Franqueza undefined(1999)undefined J Biol Chem 274 21063-undefined
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