Presence of Akkermansiaceae in gut microbiome and immunotherapy effectiveness in patients with advanced non-small cell lung cancer

被引：0
|
作者：
Anna Grenda
Ewelina Iwan
Izabela Chmielewska
Paweł Krawczyk
Aleksandra Giza
Arkadiusz Bomba
Małgorzata Frąk
Anna Rolska
Michał Szczyrek
Robert Kieszko
Tomasz Kucharczyk
Bożena Jarosz
Dariusz Wasyl
Janusz Milanowski
机构：
[1] Medical University of Lublin,Department of Pneumonology, Oncology and Allergology
[2] National Veterinary Research Institute,Department of Omics Analyses
[3] Medical University of Lublin,Chair and Department of Neurosurgery and Pediatric Neurosurgery
来源：
AMB Express | / 12卷
关键词：
NSCLC; Response to immunotherapy; PD-1; PD-L1; Microbiome;
D O I：
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学科分类号：
摘要：
The significance of Akkermansia bacteria presence in gut micobiome, mainly Akkermansia mucinifila, is currently being investigated in the context of supporting therapy and marker for response to immunotherapy in cancer patients. It is indicated that patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs) respond better to treatment if this bacterium is present in the intestine.
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