Interleukin-6 Serum Levels in Patients with Parkinson’s Disease

被引：0
作者：
Kerly Wollmeister Hofmann
Artur Francisco Schumacher Schuh
Jonas Saute
Raquel Townsend
Daniele Fricke
Renata Leke
Diogo O. Souza
Luis Valmor Portela
Márcia Lorena Fagundes Chaves
Carlos R. M. Rieder
机构：
[1] Serviço de Neurologia,
[2] Hospital de Clínicas de Porto Alegre,undefined
[3] Departamento de Bioquímica,undefined
[4] ICBS,undefined
[5] UFRGS,undefined
来源：
Neurochemical Research | 2009年 / 34卷
关键词：
Interleukin-6; Parkinson’s disease; Cytokines; Levodopa;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Several lines of evidence suggest that neuroimmune mechanisms may be involved in the neurodegenerative process of Parkinson’s disease (PD). Interleukin-6 (IL-6) is increased in the nigrostriatal region and in the cerebrospinal fluid of patients with PD. IL-6 serum level was evaluated in PD patients. The effects of levodopa treatment and disease severity on IL-6 were also studied. The IL-6 levels were similar between PD patients (treated and not treated) and controls. However, there was a negative correlation of IL-6 levels and the activities of daily living scale (P < 0.05), indicating that patients with more severe disease have higher levels of this cytokine. No correlation involving levodopa treatment and IL-6 serum level was found. The results suggest that only marginal effects of IL-6 occur on the peripheral immune system, and that the role of IL-6 and others neuroimmune factors needs to be well elucidated on PD.
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页码：1401 / 1404
页数：3
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