Association of polymorphisms of immune response modifier genes with celiac disease and its clinical forms in the Tomsk population

被引：0
作者：
A. A. Rudko
E. I. Kondratieva
G. N. Yankina
E. V. Loshkova
V. P. Puzyrev
机构：
[1] Russian Academy of Medical Sciences,Institute of Medical Genetics, Tomsk Research Center, Siberian Division
[2] Siberian State Medical University,undefined
来源：
Molecular Biology | 2008年 / 42卷
关键词：
celiac disease; genetic predisposition; candidate genes; polymorphism; cytokines;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Association of different alleles of immune response modifier genes IL1B (+3953A1/A2), IL1RN (VNTR), IL4 (3′-UTR G/C), IL4RA (I50V), IL12B (1188A/C), and VDR (F/f and B/b) with celiac disease (CD) and its clinical forms was investigated in a family cohort of CD patients from the Tomsk region (N = 139, including 49 probands, i.e., affected children). The control group comprised 129 healthy Russians from Tomsk. A case-control study did not associate any of the polymorphic markers with CD. In a family-based study, the 3′-UTR G/C polymorphism of IL4 was associated with CD (P = 0.024), its atypical form (P = 0.001), and its complications such as osteopenia (P = 0.039) and autoimmune thyroiditis (P = 0.042). IL4RA and VDR polymorphisms I50V and F/f were associated with the typical form of CD (P = 0.001 and P = 0.009, respectively). In general, associations with CD phenotypes were shown primarily for polymorphisms of the genes involved in Th2 immunity.
引用
收藏
页码：37 / 43
页数：6
相关论文
共 65 条
  • [1] Bel’mer S.V.(2004)Protocol for diagnosis and treatment of celiac disease in children: A project Vopr. Det. Dietol. 2 87-103
  • [2] Popat S.(2002)Genome screening of celiac disease J. Med. Genet. 39 328-331
  • [3] Bevan S.(2004)Possibilities and problems of modern laboratory diagnosis of celiac disease (lecture) Klin. Lab. Diagn. 11 25-32
  • [4] Braegger C.P.(2005)A pedigree-based linkage study of celiac disease: Failure to replicate previous positive findings Ann. Hum. Genet. 62 25-32
  • [5] Vokhmyatina N.V.(1999)Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1β on tuberculosis J. Exp. Med. 189 1863-1873
  • [6] Bai J.(1993)Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable number of an 86-bp tandem repeat Hum. Genet. 91 403-404
  • [7] Fried M.(2002)Ingterrelation of polymorphic variants of interleukin genes and their receptors with atopic bronchial asthma Med. Genet. 1 86-92
  • [8] Corazza G.R.(1998)Ile50Val variants or IL4Rα upregulates IgE synthesis and associates with atopic asthma Nature Genet. 19 119-120
  • [9] Wilkinson R.J.(2000)Genetic polymorphism of IL-12 p40 gene in immunemediated disease Genes Immun. 1 219-224
  • [10] Patel P.(2000)Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: A case-control study Lancet. 355 618-621
1234567