Glutamate and GABA-Metabolizing Enzymes in Post-mortem Cerebellum in Alzheimer’s Disease: Phosphate-Activated Glutaminase and Glutamic Acid Decarboxylase

被引：0
作者：
G. Sh. Burbaeva
I. S. Boksha
E. B. Tereshkina
O. K. Savushkina
T. A. Prokhorova
E. A. Vorobyeva
机构：
[1] Russian Academy of Medical Sciences,Mental Health Research Center
[2] Russian Academy of Medical Sciences,Laboratory of Neurochemistry, Mental Health Research Center
来源：
The Cerebellum | 2014年 / 13卷
关键词：
Phosphate-activated glutaminase; Glutamic acid decarboxylase; GABA metabolism; Glutamate metabolism; Alzheimer’s disease; Autopsied cerebellum;
D O I：
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学科分类号：
摘要：
Enzymes of glutamate and GABA metabolism in postmortem cerebellum from patients with Alzheimer’s disease (AD) have not been comprehensively studied. The present work reports results of original comparative study on levels of phosphate-activated glutaminase (PAG) and glutamic acid decarboxylase isoenzymes (GAD65/67) in autopsied cerebellum samples from AD patients and matched controls (13 cases in each group) as well as summarizes published evidence for altered levels of PAG and GAD65/67 in AD brain. Altered (decreased) levels of these enzymes and changes in links between amounts of these enzymes and other glutamate-metabolizing enzymes (such as glutamate dehydrogenase and glutamine synthetase-like protein) in AD cerebella suggest significantly impaired glutamate and GABA metabolism in this brain region, which was previously regarded as not substantially involved in AD pathogenesis.
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页码：607 / 615
页数：8
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