Glutamate and GABA-Metabolizing Enzymes in Post-mortem Cerebellum in Alzheimer’s Disease: Phosphate-Activated Glutaminase and Glutamic Acid Decarboxylase

被引:0
作者
G. Sh. Burbaeva
I. S. Boksha
E. B. Tereshkina
O. K. Savushkina
T. A. Prokhorova
E. A. Vorobyeva
机构
[1] Russian Academy of Medical Sciences,Mental Health Research Center
[2] Russian Academy of Medical Sciences,Laboratory of Neurochemistry, Mental Health Research Center
来源
The Cerebellum | 2014年 / 13卷
关键词
Phosphate-activated glutaminase; Glutamic acid decarboxylase; GABA metabolism; Glutamate metabolism; Alzheimer’s disease; Autopsied cerebellum;
D O I
暂无
中图分类号
学科分类号
摘要
Enzymes of glutamate and GABA metabolism in postmortem cerebellum from patients with Alzheimer’s disease (AD) have not been comprehensively studied. The present work reports results of original comparative study on levels of phosphate-activated glutaminase (PAG) and glutamic acid decarboxylase isoenzymes (GAD65/67) in autopsied cerebellum samples from AD patients and matched controls (13 cases in each group) as well as summarizes published evidence for altered levels of PAG and GAD65/67 in AD brain. Altered (decreased) levels of these enzymes and changes in links between amounts of these enzymes and other glutamate-metabolizing enzymes (such as glutamate dehydrogenase and glutamine synthetase-like protein) in AD cerebella suggest significantly impaired glutamate and GABA metabolism in this brain region, which was previously regarded as not substantially involved in AD pathogenesis.
引用
收藏
页码:607 / 615
页数:8
相关论文
共 240 条
  • [1] Fujiwara T(2013)A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration Biochem Biophys Res Commun 440 359-63
  • [2] Morimoto K(2013)AMPA receptor activation promotes non-amyloidogenic amyloid precursor protein processing and suppresses neuronal amyloid-β production PLoS One 8 e78155-60
  • [3] Hoey SE(2013)Dysregulation of synaptic and extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-β Neurosci Bull 29 752-95
  • [4] Buonocore F(2013)The potential role of kynurenines in Alzheimer’s disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors J Neural Transm 26 488-19
  • [5] Cox CJ(2004)1H-MRS evaluation of metabolism in Alzheimer’s disease and vascular dementia Neurol Res 69 705-51
  • [6] Hammond VJ(2004)Coupling between neuronal and glial cells via glutamate metabolism in brain of healthy persons and patients with mental disorders Biochemistry (Mosc) 30 1443-63
  • [7] Perkinton MS(2005)Glutamate metabolizing enzymes in prefrontal cortex of Alzheimer’s disease patients Neurochem Res 6 55-511
  • [8] Williams RJ(2011)Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer’s disease mouse model: mechanism for deficient glutamatergic transmission? Mol Neurodegener 61 1495-94
  • [9] Wang ZC(2012)Ammonium metabolism in humans Metabolism 44 788-43
  • [10] Zhao J(2006)Glutamine: a Trojan horse in ammonia neurotoxicity Hepatology 1 332-49