Construction and evaluation of the hydroxypropyl methyl cellulose-sodium alginate composite hydrogel system for sustained drug release

被引:1
作者
Yan Hu
Shangwen Zhang
Dandan Han
Zongxian Ding
Suying Zeng
Xincai Xiao
机构
[1] South-Central University for Nationalities,School of Pharmaceutical Science
[2] South-Central University for Nationalities,National Demonstration Center for Experimental Ethnopharmacology Education
来源
Journal of Polymer Research | 2018年 / 25卷
关键词
Composite hydrogel; Hydroxypropyl methyl cellulose; Sodium alginate; Chitosan; Drug release;
D O I
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中图分类号
学科分类号
摘要
We prepared a hydroxypropyl methyl cellulose-sodium alginate (HPMC-SA) composite hydrogel with a membrane covering the semi-interpenetrating network based on a semi-synthetic polymer hydroxypropyl methyl cellulose (HPMC) and a natural polymer sodium alginate (SA) by Ca2+ crosslinking and polyelectrolyte complexation with chitosan (CS) covering the hydrogel surface. The physiochemical properties of HPMC-SA hydrogels were evaluated by scanning electron microscopy, infrared spectrum, X-ray diffraction, and thermogravimetric analysis. The swelling ratio of the HPMC-SA composite hydrogel in simulated gastrointestinal fluid was measured. The drug release behavior of the HPMC-SA composite hydrogel for macro-molecular and small-molecule drugs was evaluated by using bovine serum albumin, metformin hydrochloride, and indomethacin as model drugs. The results showed that the HPMC-SA hydrogel had good water absorption and degradability, an increased swelling ratio of 55, and a prolonged time for maximum swelling degree of 50 h. Moreover, the hydrogel exhibited higher drug-loading capacity and improvements in the sustained release of bio-macromolecules, demonstrating its potential as a drug carrier for biomedical applications.
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