4-hydroxy-2-quinolones. 108. N-R-amides of 9-fluoro-1-hydroxy-5-methyl-3- oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid and their antitubercular activity

被引：0

作者：

Ukrainets I.V. ^{[1
]}

Sidorenko L.V. ^{[1
]}

Gorokhova O.V. ^{[1
]}

Shishkin O.V. ^{[2
]}

Turov A.V. ^{[3
]}

机构：

[1] National Pharmaceutical University

[2] Institute of Scintillation Materials, Ukraine National Academy of Sciences

[3] Taras Shevchenko National University

来源：

Chemistry of Heterocyclic Compounds | 2006年 / 42卷 / 9期

关键词：

4-hydroxy-2-oxo-1,2-dihydroquinoline-3- carboxylic acid esters and amides; Antitubercular activity; Heterocyclic tricarbonylmethanes; X-ray structural analysis;

D O I：

10.1007/s10593-006-0228-6

中图分类号：

学科分类号：

摘要：

The reaction of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline with triethylmethanetricarboxylate gives di(9-fluoro-1-hydroxy-5-methyl-3-oxo-6,7- dihydro-3H,5H-pyrido[3,2,1-ij]quinolin-2-yl)methane and ethyl 9-fluoro-1-hydroxy-5-methyl-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij] quinoline-2-carboxylate from which alkyl-, dialkylaminoalkyl-, and hetarylamides as well as hydrazides were prepared. The structure and antitubercular properties of the compounds synthesized are discussed. © Springer Science+Business Media, Inc. 2006.

引用

页码：1208 / 1222

页数：14

共 22 条

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