Laryngopharyngeal reflux: The value of otolaryngology examination

被引:28
作者
Belafsky P.C. [1 ]
Rees C.J. [1 ]
机构
[1] Center for Voice and Swallowing, Department of Otolaryngology Head and Neck Surgery, University of California, Sacramento, CA 95817
关键词
Vocal Fold; Symptom Index; Subglottic Stenosis; Reflux Finding Score; Vocal Process;
D O I
10.1007/s11894-008-0056-1
中图分类号
学科分类号
摘要
Laryngopharyngeal reflux (LPR) is the disease process by which gastric contents affect the extraesophageal structures of the head and neck. The symptoms of LPR include intermittent dysphonia, excessive throat clearing, globus pharyngeus, cough, and dysphagia. These symptoms can be assessed with the Reflux Symptom Index. Signs of LPR, as determined with laryngoscopy, can be described with the Reflux Findings Score, which includes assessment of site-specific laryngeal edema and other inflammatory changes. This article discusses the current understanding of LPR pathophysiology, taking into account pepsin stability and reactivation. © Springer Science+Business Media, LLC 2008.
引用
收藏
页码:278 / 282
页数:4
相关论文
共 40 条
[1]  
Koufman J.A., The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): A clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and experimental investigation of the role of acid and pepsin in the development of laryngeal injury, Laryngoscope, 101, SUPPL. 53, pp. 1-78, (1991)
[2]  
Delahunty J.E., Cherry J., Experimentally produced vocal cord granulomas, Laryngoscope, 78, pp. 1941-1947, (1968)
[3]  
Reulbach T.R., Belafsky P.C., Blalock P.D., Et al., Occult laryngeal pathology in a community-based cohort, Otolaryngol Head Neck Surg, 124, pp. 448-450, (2001)
[4]  
Axford S.E., Sharp N., Ross P.E., Et al., Cell biology of laryngeal epithelial defenses in health and disease: Preliminary studies, Ann Otol Rhinol Laryngol, 110, pp. 1099-1108, (2001)
[5]  
Johnston N., Bulmer D., Gill G., Et al., Cell biology of laryngeal epithelial defenses in health and disease: Further studies, Ann Otol Rhinol Laryngol, 112, pp. 481-491, (2003)
[6]  
Little F.B., Koufman J.A., Kohut R.I., Marshall R.B., Effect of gastric acid on the pathogenesis of subglottic stenosis, Ann Otol Rhinol Laryngol, 94, pp. 516-519, (1985)
[7]  
Johnston N., Dettmar P.W., Bishwokrama, Et al., Activity/stability of human pepsin: Implications for reflux attributed laryngeal disease, Laryngoscope, 117, pp. 1036-1039, (2007)
[8]  
Johnston N., Knight J., Dettmar P.W., Et al., Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease, Laryngoscope, 114, pp. 2129-2134, (2004)
[9]  
Koufman J.A., Belafsky P.C., Bach K.K., Et al., Prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux, Laryngoscope, 112, pp. 1606-1609, (2002)
[10]  
Groome M., Cotton J.P., Borland M., Et al., Prevalence of laryngopharyngeal reflux in a population with gastroesophageal reflux, Laryngoscope, 117, pp. 1424-1428, (2007)