Antithrombin in sepsis revisited

被引:0
作者
Marcel Levi
机构
[1] University of Amsterdam,Chairman of Medicine, Department of Vascular Medicine and Internal Medicine, Academic Medical Center
来源
Critical Care | / 9卷
关键词
Severe Sepsis; Control Clinical Trial; Antithrombin; Disseminate Intravascular Coagulation; Disseminate Intravascular Coagulation;
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摘要
As the pivotal phase III randomized controlled clinical trial on antithrombin concentrate in patients with severe sepsis did not show a beneficial effect of antithrombin treatment on 28-day mortality, the interest in the potential use of this treatment modality in sepsis has diminished. However, recent data on the effect of antithrombin administration on coagulation in combination with recent analyses from the clinical trials that were aimed to restore physiological anticoagulant pathways in patients with sepsis may revitalize the interest in antithrombin concentrate for the treatment of severe sepsis.
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