Cerebral Fungal Infection in Pediatric Cancer Patients

被引：5
作者：
Haßler A. [1 ]
Porto L. [2 ]
Lehrnbecher T. [1 ]
机构：
[1] Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Theodor-Stern-Kai 7, Frankfurt
[2] Neuroradiology Department, Johann Wolfgang Goethe-University, Frankfurt
来源：
Current Fungal Infection Reports | 2015年 / 9卷 / 1期
关键词：
Cancer; Central nervous system; Child; Hematopoietic stem cell transplantation; Invasive fungal infection;
D O I：
10.1007/s12281-014-0213-y
中图分类号：
学科分类号：
摘要：
Invasive fungal disease (IFD) significantly contributes to morbidity and mortality in pediatric cancer patients, especially in those with acute leukemia and allogeneic hematopoietic stem cell transplantation. Cerebral fungal infections are a particular severe form of IFD, as they are difficult to diagnose and require aggressive treatment, and cure rates are still unacceptably low. Here, we review the current data on epidemiology, diagnosis, and the management of cerebral fungal infection in pediatric cancer patients and outline important questions which have to be addressed by further research. © 2015, Springer Science+Business Media New York.
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页码：6 / 14
页数：8
相关论文
共 85 条
[81]  
Black K.E., Baden L.R., Fungal infections of the CNS: treatment strategies for the immunocompromised patient, CNS Drugs, 21, pp. 293-318, (2007)
[82]  
CK S., Bariola J.R., Current antifungal agents for treatment of central nervous system infections, Curr Fungal Infect Rep, 8, pp. 146-152, (2014)
[83]  
Schwartz S., Ruhnke M., Ribaud P., Et al., Improved outcome in central nervous system aspergillosis, using voriconazole treatment, Blood, 106, pp. 2641-2645, (2005)
[84]  
Mikulska M., Novelli A., Aversa F., Et al., Voriconazole in clinical practice, J Chemother, 24, pp. 311-327, (2012)
[85]  
Morris A.M., Review: voriconazole for prevention or treatment of invasive fungal infections in cancer with neutropenia, Ann Intern Med, 161, (2014)
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