Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine, folate and vitamin B12 in coronary artery disease

被引：0
作者：
Makbule Aydin
Cahide Gokkusu
Elif Ozkok
Feti Tulubas
Yesim Unlucerci
Burak Pamukcu
Zeynep Ozbek
Berrin Umman
机构：
[1] Istanbul University,Department of Neuroscience, The Institute for Experimental Medicine
[2] Istanbul University,Department of Biochemistry, Istanbul Medical Faculty
[3] Istanbul University,Department of Cardiology, Istanbul Medical Faculty
[4] Eyup State Hospital,undefined
来源：
Molecular and Cellular Biochemistry | 2009年 / 325卷
关键词：
B12; CAD; Folate; MTHFR; PON1; Polymorphism; Homocysteine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background The aim of the present study was to investigate the association between genetic variants in metylenetetrahydrofolate reductase (MTHFR) and Paraoxonase-1 (PON1) 55/192 genes and total homocysteine (tHcy), folate, B12 vitamin, and PON1 levels in patients with coronary artery disease (CAD). Methods The study included 235 patients with CAD and 268 healthy control subjects. Results LL and LM genotypes and L allele of PON1 55 were over-represented in patients. In contrast, MM genotype and M allele were more frequent in controls. QQ genotype and Q allele of PON1 192 and CT genotype of MTHFR were significantly diminished and QR genotype and R allele were significantly elevated in CAD patients compared with controls. The plasma tHcy were elevated but B12 levels were diminished in patients. PON1 55 and 192 genetic variants were significantly associated with PON1 activity, triglyceride, total cholesterol, tHcy and, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol in patients, respectively. Conclusion Genetic variants of PON1 55/192 and MTHFR were associated with CAD.
引用
收藏
页码：199 / 208
页数：9
相关论文
共 196 条
  • [1] Kerkeni M(2006)Heart disease and stroke statistics-2006 update. A report from the American heart association statistics committee and stroke statistics subcommittee Circulation 113 e85-e151
  • [2] Addad F(2006)Hyperhomocysteinemia, paraoxonase activity and risk of coronary artery disease Clin Biochem 39 821-825
  • [3] Chauffert M(2008)Homocysteine: the Rubik’s cube of cardiovascular risk factors Mayo Clin Proc 83 1200-1202
  • [4] Milani RV(2008)Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis Mayo Clin Proc 83 1203-1212
  • [5] Lavie CJ(2008)Two types of seizures in homocysteine thiolactone-treated adult rats, behavioral and electroencephalographic study Cell Mol Neurobiol 346 476-483
  • [6] Humphrey LL(2002)Plasma homocysteine as a risk factor dementia and Alzheimer’s disease N Engl J Med 43 414-421
  • [7] Fu R(1988)Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase Am J Hum Genet 20 584-592
  • [8] Rogers K(1999)The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk for coronary artery disease Eur Heart J 10 111-113
  • [9] Freeman M(1995)A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nat Genet 365 224-232
  • [10] Helfand M(2005)Homocysteine and stroke: evidence on a causal link from Mendelian randomization Lancet 6 37-46
12345678910