Endovascular treatment of CCSVI in patients with multiple sclerosis: clinical outcome of 462 cases

被引：0
作者：
A. Ghezzi
P. Annovazzi
E. Cocco
G. Coarelli
A. Lugaresi
M. Rovaris
F. Patti
E. Capello
M. E. Rodegher
L. Moiola
S. Malucchi
G. Salemi
N. De Rossi
L. Provinciali
P. Perini
R. Bergamaschi
E. Scarpini
G. Lus
A. Gallo
M. R. Tola
M. P. Amato
M. R. Rottoli
A. Bianchi
G. Comi
机构：
[1] Centro Studi Sclerosi Multipla,Centro Sclerosi Multipla, Dipartimento di Sanità Pubblica, Medicina Clinica e Molecolare
[2] Ospedale di Gallarate,Centre for Experimental Neurological Therapies (CENTERS), Neurology and Department of Neurosciences, Mental Health and Sensory Organs
[3] University of Cagliari,Multiple Sclerosis Center, Department of Neuroscience and Imaging
[4] Sapienza University S. Andrea Hospital-Rome,DANA GF Ingrassia, Neuroscience Section, Multiple Sclerosis Center
[5] Università “G d’Annunzio” Chieti,Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health
[6] Multiple Sclerosis Center,Department of Neurology, San Raffaele Scientific Institute
[7] Fondazione Don Gnocchi,Centro per la “Diagnosi e Cura delle Malattie Demielinizzanti” Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
[8] University of Catania,Clinica Neurologica
[9] University of Genova,Neurological Department
[10] Vita-Salute San Raffaele University,First Division of Neurology, Department of Clinical and Experimental Medicine and Surgery
[11] Neurologia 2-CRESM,II Clinica Neurologica, Dip.to di Scienze Mediche, Chirurgiche, Neurologiche, Metaboliche e dell’Invecchiamento
[12] AOU San Luigi Gonzaga,Department of Neurosciences
[13] Università degli Studi di Palermo,Dipartimento di Chirurgia del Sistema Nervoso e Neuroscienze, Multiple Sclerosis Center
[14] U.S.D Neurologia,undefined
[15] Centro Regionale per la Sclerosi Multipla,undefined
[16] Spedali Civili Brescia,undefined
[17] Presidio di Montichiari,undefined
[18] Università Politecnica delle Marche,undefined
[19] Azienda Ospedaliera Università’ di Padova,undefined
[20] Centro di Ricerca Interdipartimentale per la Sclerosi Multipla (CRISM),undefined
[21] Istituto Neurologico Nazionale ‘C. Mondino’,undefined
[22] Clinica Neurologica,undefined
[23] Fondazione Cà Granda Ospedale Policlinico,undefined
[24] Second University of Naples,undefined
[25] Seconda Università di Napoli,undefined
[26] Unità Operativa di Neurologia Azienda Ospedaliero,undefined
[27] Universitaria S. Anna Ferrara,undefined
[28] University of Florence,undefined
[29] Ospedali Riuniti Bergamo,undefined
来源：
Neurological Sciences | 2013年 / 34卷
关键词：
Multiple sclerosis; CCSVI; Endovascular treatment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although it is still debated whether chronic cerebro-spinal venous insufficiency (CCSVI) plays a role in multiple sclerosis (MS) development, many patients underwent endovascular treatment (ET) of CCSVI. The objective of the study is to evaluate the outcome and safety of ET in Italian MS patients. Italian MS centers that are part of the Italian MS Study Group were all invited to participate to this retrospective study. A structured questionnaire was used to collect detailed clinical data before and after the ET. Data from 462 patients were collected in 33 centers. ET consisted of balloon dilatation (93 % of cases) or stent application. The mean follow-up duration after ET was 31 weeks. Mean EDSS remained unchanged after ET (5.2 vs. 4.9), 144 relapses occurred in 98/462 cases (21 %), mainly in RR-MS patients. Fifteen severe adverse events were recorded in 3.2 % of cases. Given the risk of severe adverse events and the lack of objective beneficial effects, our findings confirm that at present ET should not be recommended to patients with MS.
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页码：1633 / 1637
页数：4
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