C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

被引：0
作者：
N J Timpson
B G Nordestgaard
R M Harbord
J Zacho
T M Frayling
A Tybjærg-Hansen
G Davey Smith
机构：
[1] MRC Centre for Causal Analysis in Translational Epidemiology,Department of Clinical Biochemistry
[2] Bristol University,Department of Social Medicine
[3] Faculty of Health Sciences,Department of Clinical Biochemistry
[4] Herlev Hospital,undefined
[5] Copenhagen University Hospital,undefined
[6] University of Copenhagen,undefined
[7] Faculty of Health Sciences,undefined
[8] The Copenhagen General Population Study,undefined
[9] Herlev Hospital,undefined
[10] Copenhagen University Hospital,undefined
[11] University of Copenhagen,undefined
[12] Bristol University,undefined
[13] Genetics of Complex Traits,undefined
[14] Institute of Biomedical and Clinical Science,undefined
[15] Peninsula Medical School,undefined
[16] Diabetes Genetics,undefined
[17] Institute of Biomedical and Clinical Science,undefined
[18] Peninsula Medical School,undefined
[19] Faculty of Health Sciences,undefined
[20] Rigshospitalet,undefined
[21] Copenhagen University Hospital,undefined
[22] University of Copenhagen,undefined
来源：
International Journal of Obesity | 2011年 / 35卷
关键词：
Mendelian randomization; hsCRP; BMI;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：300 / 308
页数：8
相关论文
共 222 条
  • [1] Yudkin JS(1999)C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19 972-978
  • [2] Stehouwer CD(2010)C-reactive protein concentration and risk of coronary disease, stroke, and mortality: an individual participant meta-analysis Lancet 375 132-140
  • [3] Emeis JJ(2004)Inflammation: the link between insulin resistance, obesity and diabetes Trends Immunol 25 4-7
  • [4] Coppack SW(1998)Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss J Clin Endocrinol Metab 83 2907-2910
  • [5] Collaboration TERF(1999)Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study Lancet 353 1649-1652
  • [6] Dandona P(2004)Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences Circulation 109 3022-3028
  • [7] Aljada A(2005)Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation J Am Coll Cardiol 46 1112-1113
  • [8] Bandyopadhyay A(1991)How independent are ‘independent’ effects? Relative risk estimation when correlated exposures are measured imprecisely J Clin Epidemiol 44 1223-1231
  • [9] Dandona P(2001)Reflections on the limitations to epidemiology J Clin Epidemiol 54 325-331
  • [10] Weinstock R(2004)Mendelian randomisation: prospects, potentials and limitations Int J Epidemiol 33 30-42
12345678910