Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation

被引：0
作者：
Xinyan Qu
Xiaoran Ding
Ming Duan
Jing Yang
Ruxian Lin
Zhe Zhou
Shengqi Wang
机构：
[1] Beijing Institute of Radiation Medicine,Shandong Analysis and Test Center
[2] Shandong Academy of Sciences,Institute of Zoonoses
[3] Jilin University,undefined
来源：
Archives of Virology | 2017年 / 162卷
关键词：
A549 Cell; Influenza Virus; Mitochondrial Membrane Potential; Viral Titer; Influenza Virus Infection;
D O I：
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中图分类号：
学科分类号：
摘要：
It is recognized that influenza virus induces caspase-dependent apoptosis by activating caspase-3. Apoptosis-inducing factor (AIF) is a caspase-independent cell death effector, and its mitochondrial-nuclear translocation plays an important role in apoptosis. It is demonstrated in this study how influenza virus infection can induce caspase-independent apoptosis in the human alveolar epithelial cell line A549. AIF is translocated from the mitochondria to the nucleus in a caspase-independent manner in response to infection with influenza virus. Knockdown of AIF expression by small interfering RNA (siRNA) led to a reduction in virus-infection-induced apoptosis and virus yield. These results indicate that AIF translocation has a role in influenza-virus-induced apoptosis.
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页码：669 / 675
页数：6
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