Muscle-invasive bladder cancer (MIBC) is an aggressive disease associated with high morbidity and mortality. In this Perspective, the authors describe the timeline of advances in treating MIBC, including radical cystectomy with pelvic lymph node dissection, the creation of increasingly sophisticated urinary diversions, use of cisplatin-based neoadjuvant chemotherapy, bladder-sparing protocols, and immunotherapy.
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Med Univ Vienna, Vienna Gen Hosp, Ctr Comprehens Canc, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, AustriaMed Univ Vienna, Vienna Gen Hosp, Ctr Comprehens Canc, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria
Grubmueller, Bernhard
Seitz, Christian
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Med Univ Vienna, Vienna Gen Hosp, Ctr Comprehens Canc, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, AustriaMed Univ Vienna, Vienna Gen Hosp, Ctr Comprehens Canc, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria
Seitz, Christian
Shariat, Shahrokh F.
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Med Univ Vienna, Vienna Gen Hosp, Ctr Comprehens Canc, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria
Cornell Univ, Weill Med Coll, New York, NY 10021 USA
UT Southwestern, Dallas, TX USAMed Univ Vienna, Vienna Gen Hosp, Ctr Comprehens Canc, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria
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Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USAOregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USA
Selph, Shelley S.
Buckley, David I.
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Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USAOregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USA
Buckley, David I.
Gustafson, Katie S.
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Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USAOregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USA
Gustafson, Katie S.
Griffin, Jessica C.
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Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USAOregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USA
Griffin, Jessica C.
Grusing, Sara E.
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Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USAOregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USA
Grusing, Sara E.
Gore, John L.
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Univ Washington, Dept Urol, Pacific Northwest Evidence Based Practice Ctr, CHASE Alliance, Seattle, WA 98195 USAOregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Pacific Northwest Evidence Based Practice Ctr, 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USA