Cholangiocarcinoma

被引:9
作者
Chahal P. [1 ]
Baron T.H. [1 ]
机构
[1] Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, 200 First Street SW
关键词
Cholangiocarcinoma; Hilar Cholangiocarcinoma; Bile Duct Carcinoma; Plastic Stents; Brush Cytology;
D O I
10.1007/s11938-005-0036-6
中图分类号
学科分类号
摘要
Cholangiocarcinoma is an uncommon malignant tumor arising from biliary epithelium. The incidence increases with age and usually affects individuals in their sixth or seventh decade of life. Most patients clinically present with features of biliary obstruction. Although surgical resection offers the only hope for cure, the majority of patients are found to have unresectable disease on initial presentation and carry extremely grim prognosis. This has lead to an emphasis on the role of palliative care, with the relief of biliary obstruction being the primary goal in the management of these patients. Surgical bypass was once considered as the primary means of palliating biliary obstruction, but nonsurgical placement of biliary stents is associated with lower morbidity and mortality. Newer modalities such as photodynamic therapy, brachytherapy, and high-intensity ultrasound therapy may result in improved survival and play a future role as an adjunctive therapy to surgical resection. Copyright © 2005 by Current Science Inc.
引用
收藏
页码:493 / 502
页数:9
相关论文
共 56 条
[1]  
Nakeeb A., Pitt H.A., Sohn T.A., Et al., Cholangiocarcinoma: A spectrum of intrahepatic, perihilar, and distal tumors, Ann Surg, 224, (1996)
[2]  
Bismuth H., Castaing D., Traynor O., Resection or palliation: Priority of surgery in the treatment of hilar cancer, World J Surg, 12, pp. 39-47, (1988)
[3]  
Chapman R.W., Risk factors for biliary tract carcinogenesis, Ann Oncol, 10, SUPPL. 4, (1999)
[4]  
de Groen P.C., Gores G.J., LaRusso N.F., Et al., Biliary tract cancers, N Engl J Med, 341, (1999)
[5]  
Chamberlain R.S., Blumgart L.H., Hilar cholangiocarcinoma: A review and commentary, Ann Surg Oncol, 7, pp. 55-66, (2000)
[6]  
Henke A.C., Jensen C.S., Cohen M.B., Cytologic diagnosis of adenocarcinoma in biliary and pancreatic duct brushings, Adv Anat Pathol, 9, pp. 301-308, (2002)
[7]  
Sugiyama M., Atomi Y., Wada N., Et al., Endoscopic transpapillary bile duct biopsy without sphincterotomy for diagnosing biliary strictures: A prospective comparison with bile and brush cytology, Am J Gastroenterol, 91, (1996)
[8]  
Ponchon T., Gagnon P., Berger F., Et al., Value of endobiliary brush cytology and biopsies for the diagnosis of malignant bile duct stenosis: Results of a prospective study, Gastrointest Endosc, 2, (1995)
[9]  
Kubota Y., Takaoka M., Tani K., Et al., Endoscopic transpapillary biopsy for diagnosis of patients with pancreaticobiliary ductal strictures, Am J Gastroenterol, 88, (1993)
[10]  
Rabinovitz M., Zajko A.B., Hassanein T., Et al., Diagnostic value of brush cytology in the diagnosis of bile duct carcinoma: A study in 65 patients with bile duct strictures, Hepatology, 12, (1990)