Clinical significance of neutrophil extracellular traps biomarkers in thrombosis

被引：0
作者：
Xiangbo Xu
Yuting Wu
Shixue Xu
Yue Yin
Walter Ageno
Valerio De Stefano
Qingchun Zhao
Xingshun Qi
机构：
[1] General Hospital of Northern Theater Command (the Teaching School of Shenyang Pharmaceutical University),Department of Gastroenterology
[2] Shenyang Pharmaceutical University,Department of Life Science and Biochemistry
[3] General Hospital of Northern Theater Command (the Teaching School of Shenyang Pharmaceutical University),Department of Pharmacy
[4] University of Insubria,Department of Medicine and Surgery
[5] Section of Hematology,Department of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico A. Gemelli IRCCS
来源：
Thrombosis Journal | / 20卷
关键词：
Neutrophil; Neutrophil extracellular traps; Thrombosis; Citrullinated histones; Myeloperoxidase;
D O I：
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中图分类号：
学科分类号：
摘要：
Neutrophil extracellular traps (NETs) may be associated with the development of thrombosis. Experimental studies have confirmed the presence of NETs in thrombi specimens and potential role of NETs in the mechanisms of thrombosis. Clinical studies also have demonstrated significant changes in the levels of serum or plasma NETs biomarkers, such as citrullinated histones, myeloperoxidase, neutrophil elastase, nucleosomes, DNA, and their complexes in patients with thrombosis. This paper aims to comprehensively review the currently available evidence regarding the change in the levels of NETs biomarkers in patients with thrombosis, summarize the role of NETs and its biomarkers in the development and prognostic assessment of venous thromboembolism, coronary artery diseases, ischemic stroke, cancer-associated thromboembolism, and coronavirus disease 2019-associated thromboembolism, explore the potential therapeutic implications of NETs, and further discuss the shortcomings of existing NETs biomarkers in serum and plasma and their detection methods.
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