Chalcone synthesis, properties and medicinal applications: a review

被引：0
作者：
Aluru Rammohan
Julakanti Satyanarayana Reddy
Gundala Sravya
Chittluri Narasimha Rao
Grigory V. Zyryanov
机构：
[1] Ural Federal University,Department of Organic and Biomolecular Chemistry
[2] Sri Venkateswara University,Department of Chemistry
[3] National Health Research Institute,Ural Division of the Russian Academy of Sciences
[4] I. Ya. Postovskiy Institute of Organic Synthesis,undefined
来源：
Environmental Chemistry Letters | 2020年 / 18卷
关键词：
Antidiabetic activity; Chalcones; Chemopreventors; Claisen–Schmidt condensation; Fluorescent material; Witting reaction;
D O I：
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中图分类号：
学科分类号：
摘要：
Chalcone is an aromatic ketone that forms the central core of many important biological compounds, which are known as chalcones. Chalcones are the biogenetic precursors of flavonoids and isoflavonoids, which are abundant in plants. Chalcones are active lead molecules in medicinal chemistry for the discovery of new drugs. Here, we review properties, biosynthesis and structural diversity of natural chalcones. Then, we present the synthesis of chalcones and their biological activities with focus on structure–activity relationships. Pharmaceutically important and patented chalcones are also discussed.
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页码：433 / 458
页数：25
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